(2R)-2-methylhex-5-en-1-yl (2R)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoate

Base Information

Chemical Name:(2R)-2-methylhex-5-en-1-yl (2R)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoate
CAS No.:1097731-62-8
Molecular Formula:C₁₇H₂₁F₃O₃
Molecular Weight:330.347
Hs Code.:

Synonyms:(2R)-2-methylhex-5-en-1-yl (2R)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R)-2-methylhex-5-en-1-yl (2R)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoate

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Technology Process of (2R)-2-methylhex-5-en-1-yl (2R)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoate

There total 3 articles about (2R)-2-methylhex-5-en-1-yl (2R)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 20445-31-2
R-(+)-α-trifluoromethyl-α-methoxy-phenylacetic acid

: 25913-88-6,142459-21-0,135006-51-8
(2R)-(+)-2-methyl-5-hexen-1-ol

: 1097731-62-8
(2R)-2-methylhex-5-en-1-yl (2R)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoate

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃; for 16h; Inert atmosphere;
DOI:10.1021/ol802562b

Reference yield:

: 25913-88-6
2-methyl-hex-5-en-1-ol

: 111688-22-3
(R)-(-)-α-methoxy-α-trifluoromethylphenylacetyl chloride

: 1097731-62-8
(2R)-2-methylhex-5-en-1-yl (2R)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoate

: 1360572-14-0
(2S)-2-methylhex-5-en-1-yl (2R)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoate

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 20 ℃; for 18h; Overall yield = 78 %; Overall yield = 23 mg;
DOI:10.1039/c5ob02023a

Reference yield:

: 1097731-59-3
(R)-N-((1S,2S)-1-hydroxy-1-phenylpropan-2-yl)-N-2-dimethylhex-5-enamide

: 1097731-62-8
(2R)-2-methylhex-5-en-1-yl (2R)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoate

Guidance literature:: Multi-step reaction with 2 steps

1: diisopropylamine; n-butyllithium; borane-ammonia complex / tetrahydrofuran; hexane / 4 h / 0 - 20 °C

2: dmap; dicyclohexyl-carbodiimide / dichloromethane / 16 h / 20 °C

With dmap; n-butyllithium; borane-ammonia complex; diisopropylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1039/c5ob00498e