(1R,3S)-3-(3-ethyl-ureido)-cyclopentanecarboxylic acid N-(4-benzooxazol-2-ylphenyl)-N-methyl-amide

Base Information

Chemical Name:(1R,3S)-3-(3-ethyl-ureido)-cyclopentanecarboxylic acid N-(4-benzooxazol-2-ylphenyl)-N-methyl-amide
CAS No.:1291779-75-3
Molecular Formula:C₂₃H₂₆N₄O₃
Molecular Weight:406.484
Hs Code.:

Synonyms:(1R,3S)-3-(3-ethyl-ureido)-cyclopentanecarboxylic acid N-(4-benzooxazol-2-ylphenyl)-N-methyl-amide

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Chemical Property of (1R,3S)-3-(3-ethyl-ureido)-cyclopentanecarboxylic acid N-(4-benzooxazol-2-ylphenyl)-N-methyl-amide

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Technology Process of (1R,3S)-3-(3-ethyl-ureido)-cyclopentanecarboxylic acid N-(4-benzooxazol-2-ylphenyl)-N-methyl-amide

There total 6 articles about (1R,3S)-3-(3-ethyl-ureido)-cyclopentanecarboxylic acid N-(4-benzooxazol-2-ylphenyl)-N-methyl-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 1291779-73-1
(1R,3S)-3-amino-cyclopentanecarboxylic acid N-(4-benzooxazol-2-yl-phenyl)-N-methyl-amide trifluoro acetic acid

: 109-90-0
ethyl isocyanate

: 1291779-75-3
(1R,3S)-3-(3-ethyl-ureido)-cyclopentanecarboxylic acid N-(4-benzooxazol-2-ylphenyl)-N-methyl-amide

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

Reference yield:

: 95-55-6
2-amino-phenol

: 1291779-75-3
(1R,3S)-3-(3-ethyl-ureido)-cyclopentanecarboxylic acid N-(4-benzooxazol-2-ylphenyl)-N-methyl-amide

Guidance literature:: Multi-step reaction with 5 steps

1.1: polyphosphoric acid / 4 h / 205 °C

2.1: 1-chloro-1-(dimethylamino)-2-methyl-1-propene / dichloromethane / 2 h

2.2: 20 °C

3.1: diethylamine / tetrahydrofuran / 20 - 40 °C

4.1: acetonitrile; water

5.1: triethylamine / N,N-dimethyl-formamide / 1 h / 20 °C

With 1-chloro-1-(dimethylamino)-2-methyl-1-propene; diethylamine; triethylamine; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 2-(p-methylaminophenyl)benzoxazole

: 1291779-75-3
(1R,3S)-3-(3-ethyl-ureido)-cyclopentanecarboxylic acid N-(4-benzooxazol-2-ylphenyl)-N-methyl-amide

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1-chloro-1-(dimethylamino)-2-methyl-1-propene / dichloromethane / 2 h

1.2: 20 °C

2.1: diethylamine / tetrahydrofuran / 20 - 40 °C

3.1: acetonitrile; water

4.1: triethylamine / N,N-dimethyl-formamide / 1 h / 20 °C

With 1-chloro-1-(dimethylamino)-2-methyl-1-propene; diethylamine; triethylamine; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;