METHYL CLONAZEPAM

Base Information

• Chemical Name: METHYL CLONAZEPAM
• CAS No.: 5527-71-9
• Molecular Formula: C16H12ClN3O3
• Molecular Weight: 329.743
• Hs Code.: 2933990090
• Mol file: 5527-71-9.mol

Synonyms:5-(2-chlorophenyl)-1-methyl-7-nitro-3H-1,4-benzodiazepin-2-one;

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Chemical Property of METHYL CLONAZEPAM

Chemical Property:

• Vapor Pressure: 7.36E-13mmHg at 25°C
• Melting Point: 194-195oC
• Boiling Point: 566.7°C at 760 mmHg
• PKA: 1.55±0.25(Predicted)
• Flash Point: 296.5°C
• PSA: 78.49000
• Density: 1.42g/cm³
• LogP: 3.08580
• Storage Temp.: Controlled Substance, -20°C Freezer

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Shows sedative and anxiolytic properties. Impairment of psychomotor performance reported. Activity blocked by flumazenil.

Technology Process of METHYL CLONAZEPAM

There total 3 articles about METHYL CLONAZEPAM which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-(2-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one (364046-84-4,364046-86-6,1622-61-3) + methyl iodide (74-88-4) → 1-methyl-5-(2'-chloro-phenyl)-7-nitro-1,3-dihydro-2H-1,4-benzodiazepin-2-one (5527-71-9)

Guidance literature:

With potassium carbonate; In dichloromethane; acetone;

Reference yield:

5-(2-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one (364046-84-4,364046-86-6,1622-61-3) → 1-methyl-5-(2'-chloro-phenyl)-7-nitro-1,3-dihydro-2H-1,4-benzodiazepin-2-one (5527-71-9)

Guidance literature:

With aluminum oxide; potassium fluoride; In acetone; for 24h; Reflux;

DOI:10.1111/j.1747-0285.2012.01354.x

Reference yield:

→ 1-methyl-5-(2'-chloro-phenyl)-7-nitro-1,3-dihydro-2H-1,4-benzodiazepin-2-one (5527-71-9)

Guidance literature:

7-Nitro-5-<2-chlor-phenyl>-1.3-dihydro-2H-1.4-benzodiazepinon-(2), 1) CH3ONa, 2) CH3I;

DOI:10.1021/jm00339a010

upstream raw materials:

5-(2-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one

methyl iodide