2-(1-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-1H-pyrazol-4-yl)acetic acid

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Chemical Name:2-(1-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-1H-pyrazol-4-yl)acetic acid
CAS No.:937060-69-0
Molecular Formula:C₂₇H₂₆ClN₃O₅
Molecular Weight:507.974
Hs Code.:

Synonyms:2-(1-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-1H-pyrazol-4-yl)acetic acid

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Chemical Property of 2-(1-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-1H-pyrazol-4-yl)acetic acid

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Technology Process of 2-(1-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-1H-pyrazol-4-yl)acetic acid

There total 11 articles about 2-(1-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-1H-pyrazol-4-yl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 937063-57-5
2-(1-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-1H-pyrazol-4-yl)acetonitrile

: 937060-69-0
2-(1-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-1H-pyrazol-4-yl)acetic acid

Guidance literature:: 2-(1-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-1H-pyrazol-4-yl)acetonitrile; With water; sodium hydroxide; In isopropyl alcohol; Reflux;

With hydrogenchloride; In water; Cooling with ice;
DOI:10.1016/j.bmc.2012.02.054

Reference yield:

: 937057-49-3
1-[4-chloro-2-(2,3-dimethoxybenzoyl)phenyl]-1H-pyrrole-2-carbaldehyde

: 937060-69-0
2-(1-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-1H-pyrazol-4-yl)acetic acid

Guidance literature:: Multi-step reaction with 11 steps

1.1: toluene / 7 h / 100 °C

2.1: sodium tetrahydroborate / methanol / 1 h / 20 °C

3.1: trifluoroacetic acid / dichloromethane / 8 h / 20 °C

4.1: CHIRALCEL OD column / hexane; isopropyl alcohol / Resolution of racemate

5.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 °C

6.1: triethylamine / dichloromethane / 3 h / 0 °C

7.1: sodium hydride / N,N-dimethyl-formamide; mineral oil

7.2: 0 °C

8.1: lithium aluminium tetrahydride / tetrahydrofuran / Cooling with ice

9.1: carbon tetrabromide; triphenylphosphine / dichloromethane / Cooling with ice

10.1: dichloromethane; dimethyl sulfoxide / Cooling with ice; Heating

11.1: water; sodium hydroxide / isopropyl alcohol / Reflux

11.2: Cooling with ice

With sodium tetrahydroborate; lithium aluminium tetrahydride; carbon tetrabromide; water; sodium hydride; triethylamine; triphenylphosphine; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; methanol; hexane; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; isopropyl alcohol; toluene; mineral oil; 1.1: Wittig reaction / 3.1: Michael reaction;
DOI:10.1016/j.bmc.2012.02.054

Reference yield:

: 937060-68-9
ethyl 1-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-1H-pyrazole-4-carboxylate

: 937060-69-0
2-(1-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-1H-pyrazol-4-yl)acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / Cooling with ice

2.1: carbon tetrabromide; triphenylphosphine / dichloromethane / Cooling with ice

3.1: dichloromethane; dimethyl sulfoxide / Cooling with ice; Heating

4.1: water; sodium hydroxide / isopropyl alcohol / Reflux

4.2: Cooling with ice

With lithium aluminium tetrahydride; carbon tetrabromide; water; triphenylphosphine; sodium hydroxide; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; isopropyl alcohol;
DOI:10.1016/j.bmc.2012.02.054