2-(1-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-1H-pyrazol-4-yl)acetonitrile

Base Information

Chemical Name:2-(1-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-1H-pyrazol-4-yl)acetonitrile
CAS No.:937063-57-5
Molecular Formula:C₂₇H₂₅ClN₄O₃
Molecular Weight:488.973
Hs Code.:

Synonyms:2-(1-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-1H-pyrazol-4-yl)acetonitrile

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Chemical Property of 2-(1-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-1H-pyrazol-4-yl)acetonitrile

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Technology Process of 2-(1-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-1H-pyrazol-4-yl)acetonitrile

There total 11 articles about 2-(1-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-1H-pyrazol-4-yl)acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 773837-37-9
sodium cyanide

: C₂₆H₂₅BrClN₃O₃

: 937063-57-5
2-(1-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-1H-pyrazol-4-yl)acetonitrile

Guidance literature:: In dichloromethane; dimethyl sulfoxide; Cooling with ice; Heating;
DOI:10.1016/j.bmc.2012.02.054

Reference yield:

: 937057-49-3
1-[4-chloro-2-(2,3-dimethoxybenzoyl)phenyl]-1H-pyrrole-2-carbaldehyde

: 937063-57-5
2-(1-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-1H-pyrazol-4-yl)acetonitrile

Guidance literature:: Multi-step reaction with 10 steps

1.1: toluene / 7 h / 100 °C

2.1: sodium tetrahydroborate / methanol / 1 h / 20 °C

3.1: trifluoroacetic acid / dichloromethane / 8 h / 20 °C

4.1: CHIRALCEL OD column / hexane; isopropyl alcohol / Resolution of racemate

5.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 °C

6.1: triethylamine / dichloromethane / 3 h / 0 °C

7.1: sodium hydride / N,N-dimethyl-formamide; mineral oil

7.2: 0 °C

8.1: lithium aluminium tetrahydride / tetrahydrofuran / Cooling with ice

9.1: carbon tetrabromide; triphenylphosphine / dichloromethane / Cooling with ice

10.1: dichloromethane; dimethyl sulfoxide / Cooling with ice; Heating

With sodium tetrahydroborate; lithium aluminium tetrahydride; carbon tetrabromide; sodium hydride; triethylamine; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; methanol; hexane; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; isopropyl alcohol; toluene; mineral oil; 1.1: Wittig reaction / 3.1: Michael reaction;
DOI:10.1016/j.bmc.2012.02.054

Reference yield:

: 937060-68-9
ethyl 1-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-1H-pyrazole-4-carboxylate

: 937063-57-5
2-(1-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-1H-pyrazol-4-yl)acetonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / Cooling with ice

2: carbon tetrabromide; triphenylphosphine / dichloromethane / Cooling with ice

3: dichloromethane; dimethyl sulfoxide / Cooling with ice; Heating

With lithium aluminium tetrahydride; carbon tetrabromide; triphenylphosphine; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide;
DOI:10.1016/j.bmc.2012.02.054