N-tert-butoxycarbonyl-D-phenylalanyl-L-cysteinyl(Acm)-D-tryptophyl-α-azaleucinamide

Base Information

Chemical Name:N-tert-butoxycarbonyl-D-phenylalanyl-L-cysteinyl(Acm)-D-tryptophyl-α-azaleucinamide
CAS No.:128718-69-4
Molecular Formula:C₃₆H₅₀N₈O₇S
Molecular Weight:738.908
Hs Code.:

Synonyms:N-tert-butoxycarbonyl-D-phenylalanyl-L-cysteinyl(Acm)-D-tryptophyl-α-azaleucinamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-tert-butoxycarbonyl-D-phenylalanyl-L-cysteinyl(Acm)-D-tryptophyl-α-azaleucinamide

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Technology Process of N-tert-butoxycarbonyl-D-phenylalanyl-L-cysteinyl(Acm)-D-tryptophyl-α-azaleucinamide

There total 9 articles about N-tert-butoxycarbonyl-D-phenylalanyl-L-cysteinyl(Acm)-D-tryptophyl-α-azaleucinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.6%

: 98138-27-3
Azleu-NH₂

: 128719-33-5
Boc-D-Phe-Cys(Acm)-D-Trp-OH

: 128718-69-4
N-tert-butoxycarbonyl-D-phenylalanyl-L-cysteinyl(Acm)-D-tryptophyl-α-azaleucinamide

Guidance literature:: With benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; at 4 ℃;

Reference yield:

: 19746-37-3
N-t-butoxycarbonyl-S-acetamidomethyl-L-cysteine

: 128718-69-4
N-tert-butoxycarbonyl-D-phenylalanyl-L-cysteinyl(Acm)-D-tryptophyl-α-azaleucinamide

Guidance literature:: Multi-step reaction with 6 steps

1: N-methylmorpholine / dimethylformamide / 0.03 h

2: Et₃N / dimethylformamide / 1.) -10 deg C, 30 min, 2.) 4 deg C, 2 h

3: 88 percent / 2N HCl / ethyl acetate / 1 h / Ambient temperature

4: Et₃N / dimethylformamide / 1.) -10 deg C, 30 min, 2.) 4 deg C, 2 h

5: 93.2 percent / 2N NaOH / methanol / 1 h / Ambient temperature

6: 66.6 percent / dicyclohexylcarbodiimide (DCCI), 1-hydroxybenzotriazole (HOBt), Et₃N / dimethylformamide / 4 °C

With 4-methyl-morpholine; hydrogenchloride; sodium hydroxide; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In methanol; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 18942-49-9
Boc-D-Phe-OH

: 128718-69-4
N-tert-butoxycarbonyl-D-phenylalanyl-L-cysteinyl(Acm)-D-tryptophyl-α-azaleucinamide

Guidance literature:: Multi-step reaction with 4 steps

1: N-methylmorpholine / dimethylformamide / 0.03 h

2: Et₃N / dimethylformamide / 1.) -10 deg C, 30 min, 2.) 4 deg C, 2 h

3: 93.2 percent / 2N NaOH / methanol / 1 h / Ambient temperature

4: 66.6 percent / dicyclohexylcarbodiimide (DCCI), 1-hydroxybenzotriazole (HOBt), Et₃N / dimethylformamide / 4 °C

With 4-methyl-morpholine; sodium hydroxide; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In methanol; N,N-dimethyl-formamide;