2,2-Difluoro-2-[4-(trifluoromethyl)phenyl]acetic acid

Base Information

Chemical Name:2,2-Difluoro-2-[4-(trifluoromethyl)phenyl]acetic acid
CAS No.:73790-11-1
Molecular Formula:C₉H₅F₅O₂
Molecular Weight:240.13
Hs Code.:2916399090
European Community (EC) Number:828-262-9
DSSTox Substance ID:DTXSID201227378

Synonyms:2,2-difluoro-2-[4-(trifluoromethyl)phenyl]acetic acid;73790-11-1;MFCD16756774;2,2-difluoro-2-(4-(trifluoromethyl)phenyl)acetic acid;SCHEMBL23588301;DTXSID201227378;YCA79011;AC1481;AKOS011683306;AC-29772;CS-12161;SY038883;CS-0210142;EN300-1138347;2,2-difluoro-2-[4-(trifluoromethyl)phenyl]aceticacid;alpha,alpha-Difluoro-4-(trifluoromethyl)benzeneacetic acid

Suppliers and Price of 2,2-Difluoro-2-[4-(trifluoromethyl)phenyl]acetic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

SynQuest Laboratories
2,2-Difluoro-2-[4-(trifluoromethyl)phenyl]acetic acid
1 g
$ 437.00

SynQuest Laboratories
2,2-Difluoro-2-[4-(trifluoromethyl)phenyl]acetic acid
5 g
$ 1109.00

AK Scientific
2,2-Difluoro-2-[4-(trifluoromethyl)phenyl]aceticacid
5g
$ 728.00

Total 5 raw suppliers

Chemical Property of 2,2-Difluoro-2-[4-(trifluoromethyl)phenyl]acetic acid

Chemical Property:

XLogP3:3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:2
Exact Mass:240.02097021
Heavy Atom Count:16
Complexity:266

Purity/Quality:

97% ^*data from raw suppliers

2,2-Difluoro-2-[4-(trifluoromethyl)phenyl]acetic acid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC(=CC=C1C(C(=O)O)(F)F)C(F)(F)F

Technology Process of 2,2-Difluoro-2-[4-(trifluoromethyl)phenyl]acetic acid

There total 10 articles about 2,2-Difluoro-2-[4-(trifluoromethyl)phenyl]acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 73790-11-1
α,α-difluoro-4-(trifluoromethyl)benzeneacetic acid

Guidance literature:: With water; lithium hydroxide; In tetrahydrofuran; at 20 ℃; for 2h;

Reference yield: 79.0%

: 73789-96-5
ethyl α,α-difluoro-4-(trifluoromethyl)benzeneacetate

: 73790-11-1
α,α-difluoro-4-(trifluoromethyl)benzeneacetic acid

Guidance literature:: With hydrogen iodide; In acetic acid; Heating;
DOI:10.1021/jo01302a025

Reference yield:

: 667-27-6
Ethyl bromodifluoroacetate

: 455-13-0
4-Iodobenzotrifluoride

: 73790-11-1
α,α-difluoro-4-(trifluoromethyl)benzeneacetic acid

Guidance literature:: Ethyl bromodifluoroacetate; 4-Iodobenzotrifluoride; With copper; In dimethyl sulfoxide; at 60 ℃; for 12h; Inert atmosphere;

With methanol; water; potassium carbonate; at 20 ℃; for 2h; Inert atmosphere;
DOI:10.1039/d1ob01754c