Ethyl 2,2-difluoro-2-[4-(trifluoromethyl)phenyl]acetate

Base Information

Chemical Name:Ethyl 2,2-difluoro-2-[4-(trifluoromethyl)phenyl]acetate
CAS No.:73789-96-5
Molecular Formula:C₁₁H₉F₅O₂
Molecular Weight:268.183
Hs Code.:2918300090
DSSTox Substance ID:DTXSID101218108
Nikkaji Number:J3.188.299K

Synonyms:73789-96-5;ethyl 2,2-difluoro-2-[4-(trifluoromethyl)phenyl]acetate;ethyl 2,2-difluoro-2-(4-(trifluoromethyl)phenyl)acetate;SCHEMBL17583195;DTXSID101218108;AC6712;MFCD17475883;AKOS011683305;SY038882;CS-0455313;A925819;A1-11839;Ethyl alpha,alpha-difluoro-4-(trifluoromethyl)benzeneacetate;Benzeneacetic acid, alpha,alpha-difluoro-4-(trifluoromethyl)-, ethyl ester;Benzeneaceticacid,alpha,alpha-difluoro-4-(trifluoromethyl)-,ethylester

Suppliers and Price of Ethyl 2,2-difluoro-2-[4-(trifluoromethyl)phenyl]acetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

SynQuest Laboratories
Ethyl 2,2-difluoro-2-[4-(trifluoromethyl)phenyl]acetate
5 g
$ 1109.00

Matrix Scientific
Ethyl 2,2-difluoro-2-(4-(trifluoromethyl)phenyl)acetate 95%
5g
$ 1733.00

Apolloscientific
Ethyl2,2-Difluoro-2-[4-(trifluoromethyl)phenyl]acetate
5g
$ 1005.00

AK Scientific
Ethyl2,2-difluoro-2-[4-(trifluoromethyl)phenyl]acetate
5g
$ 937.00

A1 Biochem Labs
Ethyl2,2-difluoro-2-(4-(trifluoromethyl)phenyl)acetate 95%
5 g
$ 950.00

Total 3 raw suppliers

Chemical Property of Ethyl 2,2-difluoro-2-[4-(trifluoromethyl)phenyl]acetate

Chemical Property:

XLogP3:3.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:4
Exact Mass:268.05227034
Heavy Atom Count:18
Complexity:292

Purity/Quality:

97% ^*data from raw suppliers

Ethyl 2,2-difluoro-2-[4-(trifluoromethyl)phenyl]acetate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCOC(=O)C(C1=CC=C(C=C1)C(F)(F)F)(F)F

Technology Process of Ethyl 2,2-difluoro-2-[4-(trifluoromethyl)phenyl]acetate

There total 9 articles about Ethyl 2,2-difluoro-2-[4-(trifluoromethyl)phenyl]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 73789-96-5
ethyl α,α-difluoro-4-(trifluoromethyl)benzeneacetate

Guidance literature:: With copper; In dimethyl sulfoxide; at 30 - 50 ℃; for 16h; Inert atmosphere;

Reference yield: 79.0%

: 667-27-6
Ethyl bromodifluoroacetate

: 455-13-0
4-Iodobenzotrifluoride

: 73789-96-5
ethyl α,α-difluoro-4-(trifluoromethyl)benzeneacetate

Guidance literature:: With copper; In dimethyl sulfoxide; at 55 ℃; for 12h; Inert atmosphere;
DOI:10.1002/jhet.4367

Reference yield: 75.0%

: 667-27-6
Ethyl bromodifluoroacetate

: 145349-76-4
[4-(ethylsulfanyl)phenyl]boronic acid

: 73789-96-5
ethyl α,α-difluoro-4-(trifluoromethyl)benzeneacetate

Guidance literature:: With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; at 80 ℃; for 24h; Reagent/catalyst; Schlenk technique; Inert atmosphere; Molecular sieve;
DOI:10.1002/anie.201309535