N-[2-hydroxy-2-[3-(2-quinolinylmethoxy)phenyl]ethyl]-2-thiophene carboxamide

Base Information

Chemical Name:N-[2-hydroxy-2-[3-(2-quinolinylmethoxy)phenyl]ethyl]-2-thiophene carboxamide
CAS No.:110193-31-2
Molecular Formula:C₂₃H₂₀N₂O₃S
Molecular Weight:404.489
Hs Code.:

Synonyms:N-[2-hydroxy-2-[3-(2-quinolinylmethoxy)phenyl]ethyl]-2-thiophene carboxamide

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Chemical Property of N-[2-hydroxy-2-[3-(2-quinolinylmethoxy)phenyl]ethyl]-2-thiophene carboxamide

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Technology Process of N-[2-hydroxy-2-[3-(2-quinolinylmethoxy)phenyl]ethyl]-2-thiophene carboxamide

There total 6 articles about N-[2-hydroxy-2-[3-(2-quinolinylmethoxy)phenyl]ethyl]-2-thiophene carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 110193-39-0
4,5-dihydro-5-[3-[(2-quinolinyl)methoxy]phenyl]-2-(thien-2-yl)-1,3-oxazole

: 110193-31-2
N-[2-hydroxy-2-[3-(2-quinolinylmethoxy)phenyl]ethyl]-2-thiophene carboxamide

Guidance literature:: With hydrogenchloride; In acetonitrile; for 5h; Heating;
DOI:10.1021/jm00394a026

Reference yield:

: 4377-41-7
2-Chloromethylquinoline

: 110193-31-2
N-[2-hydroxy-2-[3-(2-quinolinylmethoxy)phenyl]ethyl]-2-thiophene carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: 38 percent / sodium methoxide / dimethylformamide / 16 h / 90 °C

2: 48 percent / conc. HCl / acetonitrile / 5 h / Heating

With hydrogenchloride; sodium methylate; In N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm00394a026

Reference yield:

: 54610-60-5
methyl 2-thiophene carboximidate

: 110193-31-2
N-[2-hydroxy-2-[3-(2-quinolinylmethoxy)phenyl]ethyl]-2-thiophene carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: tetrahydrofuran / 16 h / Heating

2: 38 percent / sodium methoxide / dimethylformamide / 16 h / 90 °C

3: 48 percent / conc. HCl / acetonitrile / 5 h / Heating

With hydrogenchloride; sodium methylate; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm00394a026