4,5-dihydro-5-[3-[(2-quinolinyl)methoxy]phenyl]-2-(thien-2-yl)-1,3-oxazole

Base Information

Chemical Name:4,5-dihydro-5-[3-[(2-quinolinyl)methoxy]phenyl]-2-(thien-2-yl)-1,3-oxazole
CAS No.:110193-39-0
Molecular Formula:C₂₃H₁₈N₂O₂S
Molecular Weight:386.474
Hs Code.:

Synonyms:4,5-dihydro-5-[3-[(2-quinolinyl)methoxy]phenyl]-2-(thien-2-yl)-1,3-oxazole

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Chemical Property of 4,5-dihydro-5-[3-[(2-quinolinyl)methoxy]phenyl]-2-(thien-2-yl)-1,3-oxazole

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Technology Process of 4,5-dihydro-5-[3-[(2-quinolinyl)methoxy]phenyl]-2-(thien-2-yl)-1,3-oxazole

There total 3 articles about 4,5-dihydro-5-[3-[(2-quinolinyl)methoxy]phenyl]-2-(thien-2-yl)-1,3-oxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 4377-41-7
2-Chloromethylquinoline

: 112636-21-2
4,5-Dihydro-5-(3-hydroxyphenyl)-2-(thien-2-yl)-1,3-oxazole

: 110193-39-0
4,5-dihydro-5-[3-[(2-quinolinyl)methoxy]phenyl]-2-(thien-2-yl)-1,3-oxazole

Guidance literature:: With sodium methylate; In N,N-dimethyl-formamide; at 90 ℃; for 16h;
DOI:10.1021/jm00394a026

Reference yield:

: 54610-60-5
methyl 2-thiophene carboximidate

: 110193-39-0
4,5-dihydro-5-[3-[(2-quinolinyl)methoxy]phenyl]-2-(thien-2-yl)-1,3-oxazole

Guidance literature:: Multi-step reaction with 2 steps

1: tetrahydrofuran / 16 h / Heating

2: 38 percent / sodium methoxide / dimethylformamide / 16 h / 90 °C

With sodium methylate; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm00394a026

Reference yield:

: 4779-94-6
(+/-)-norphenylephrine hydrochloride

: 110193-39-0
4,5-dihydro-5-[3-[(2-quinolinyl)methoxy]phenyl]-2-(thien-2-yl)-1,3-oxazole

Guidance literature:: Multi-step reaction with 2 steps

1: tetrahydrofuran / 16 h / Heating

2: 38 percent / sodium methoxide / dimethylformamide / 16 h / 90 °C

With sodium methylate; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm00394a026