(+)-ethyl 6-[difluoro(phenyl)methyl]-2-phenyl-4-[(R)-p-tolylsulfinylmethyl]-1,4-dihydropyridin-3-carboxylate

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Chemical Name:(+)-ethyl 6-[difluoro(phenyl)methyl]-2-phenyl-4-[(R)-p-tolylsulfinylmethyl]-1,4-dihydropyridin-3-carboxylate
CAS No.:1235994-41-8
Molecular Formula:C₂₉H₂₇F₂NO₃S
Molecular Weight:507.601
Hs Code.:

Synonyms:(+)-ethyl 6-[difluoro(phenyl)methyl]-2-phenyl-4-[(R)-p-tolylsulfinylmethyl]-1,4-dihydropyridin-3-carboxylate

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Chemical Property of (+)-ethyl 6-[difluoro(phenyl)methyl]-2-phenyl-4-[(R)-p-tolylsulfinylmethyl]-1,4-dihydropyridin-3-carboxylate

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Technology Process of (+)-ethyl 6-[difluoro(phenyl)methyl]-2-phenyl-4-[(R)-p-tolylsulfinylmethyl]-1,4-dihydropyridin-3-carboxylate

There total 2 articles about (+)-ethyl 6-[difluoro(phenyl)methyl]-2-phenyl-4-[(R)-p-tolylsulfinylmethyl]-1,4-dihydropyridin-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 2002-72-4
α,α-difluorobenzeneacetonitrile

: 89708-79-2
(R)-(+)-allyl p-tolyl sulphoxide

: 2216-94-6
phenylpropynoic acid ethyl ester

: 1235994-41-8
(+)-ethyl 6-[difluoro(phenyl)methyl]-2-phenyl-4-[(R)-p-tolylsulfinylmethyl]-1,4-dihydropyridin-3-carboxylate

Guidance literature:: (R)-(+)-allyl p-tolyl sulphoxide; With potassium hexamethylsilazane; In tetrahydrofuran; toluene; at -78 ℃; for 0.5h; Inert atmosphere;

α,α-difluorobenzeneacetonitrile; In tetrahydrofuran; toluene; at -78 ℃; for 1h; Inert atmosphere;

phenylpropynoic acid ethyl ester; In tetrahydrofuran; toluene; at -78 ℃; Inert atmosphere;
DOI:10.1021/ol101318t