2002-72-4

Usage

Uses

Used in Pharmaceutical Industry:
2,2-Difluoro-2-phenylacetonitrile is used as an intermediate compound for the synthesis of various pharmaceuticals. Its unique structure and properties make it a valuable building block in the development of new drugs, particularly those targeting specific biological pathways or receptors.
Used in Chemical Synthesis:
In the chemical industry, 2,2-difluoro-2-phenylacetonitrile is used as a starting material for the synthesis of a wide range of organic compounds. Its reactivity and the presence of the nitrile group make it a versatile precursor for the production of various chemical products, including agrochemicals, dyes, and specialty chemicals.
Used in Material Science:
2,2-Difluoro-2-phenylacetonitrile is employed in the development of advanced materials, such as polymers and coatings, that exhibit unique properties due to the presence of fluorine atoms. These materials can be used in various applications, including electronics, automotive, and aerospace industries, where high-performance materials with specific characteristics are required.
Used in Research and Development:
In academic and industrial research settings, 2,2-difluoro-2-phenylacetonitrile is utilized as a model compound for studying the effects of fluorination on the properties and reactivity of organic molecules. This knowledge can be applied to the design and synthesis of new compounds with tailored properties for various applications.

InChI:InChI=1/C8H5F2N/c9-8(10,6-11)7-4-2-1-3-5-7/h1-5H

Upstream product

• 383-19-7 2,2-difluoro-2-phenylacetamide 
• 75280-10-3 α-(methylthio)phenylacetonitrile 
• 2248-46-6 ethyl 2,2-difluoro-2-phenylacetate 
• 1603-79-8 phenylglyoxylic acid ethyl ester 
• 98-88-4 benzoyl chloride 
• 40626-45-7 α,α-dichlorobenzylcyanide 

Downstream Products

• 383-19-7 2,2-difluoro-2-phenylacetamide 
• 1160957-41-4 phenyl(4-((1R,2S,3R)-1,2,3,4-tetrahydroxybutyl)-1H-imidazol-2-yl)methanone 
• 1214914-17-6 (2E,4Z)-ethyl 5-amino-6,6-difluoro-6-phenyl-2,4-hexadienoate 
• 1214914-19-8 (Z)-ethyl 3-amino-4,4-difluoro-4-phenyl-2-vinyl-2-butenoate 

Relevant academic research and scientific papers

Desulfurizing difluorination reaction of benzyl sulfides using IF 5

A desulfurizing difluorination reaction of benzyl sulfides having a functional group such as an ester, a ketone, a nitrile, or an amide was performed by a reaction with IF5. Consequently, gemdifluoro compounds could be obtained selectively. Geo

Synthesis, Characterization, and Reactivity of Palladium Fluoroenolate Complexes

Cross-coupling reactions of aryl groups with α-fluoro carbonyl compounds catalyzed by palladium complexes have been reported, but palladium fluoroenolate intermediates relevant to such reactions have not been isolated or even detected previously. We report the synthesis, structural characterization, and reactivity of a series of C-bound arylpalladium fluoroenolate complexes ligated by monophosphines and bisphosphines. DPPF-ligated arylpalladium fluoroenolate complexes (DPPF = 1,1-bis(diphenylphosphino)-ferrocene) derived from a monofluoroester, a difluoroester, difluoroamides, and difluoroacetonitrile underwent reductive elimination in high yields. Reductive elimination was faster from complexes containing less electron-withdrawing fluoroenolate groups and longer Pd-C(enolate) bonds than from complexes containing more electron-withdrawing fluoroenolate groups and shorter Pd-C(enolate) bonds. The rates of reductive elimination from these C-bound fluoroenolate complexes were significantly faster than those of the analogous trifluoromethyl complexes.

1,3-DISUBSTITUTED HETEROARYL NMDA/NR2B ANTAGONISTS

Compounds represented by Formula I: (wherein A, B, D, P, Q, R1, R2, R3, W and Y are described herein) or pharmaceutically acceptable salts thereof, are effective as NMDA/NR2B antagonists useful for treating neurological co

Fluorination of 2-oxo-ethane derivatives with diethylaminosulfur trifluoride (DAST)

The fluorination of 2-oxo-ethane derivatives with DAST is described. The use of Znl2 as a catalyst improves the yield in the fluorination of 2-phenyl-2-oxo-acetonitrile with DAST.

&α,&α-Difluoroarylacetic Acids: Preparation from (Diethylamino)sulfur Trifluoride and &α-Oxoarylacetates

Several α,α-difluoroarylacetic acids have been prepared by reaction of DAST ((diethylamino)sulfur trifluoride) with esters of α-oxoarylacetic acids and then hydrolysis of the resulting difluoro ester.Examples include the α,α-difluoro derivates of the synthetic plant auxin, α-naphthylacetic acid, and the antiinflammatory drug, ibufenac.