(4R,5S)-3-[(2R,3S)-6-Benzyloxy-3-(4-methoxy-benzyloxy)-2-methyl-hexanoyl]-4-methyl-5-phenyl-oxazolidin-2-one

Base Information

Chemical Name:(4R,5S)-3-[(2R,3S)-6-Benzyloxy-3-(4-methoxy-benzyloxy)-2-methyl-hexanoyl]-4-methyl-5-phenyl-oxazolidin-2-one
CAS No.:852244-90-7
Molecular Formula:C₃₂H₃₇NO₆
Molecular Weight:531.649
Hs Code.:

Synonyms:(4R,5S)-3-[(2R,3S)-6-Benzyloxy-3-(4-methoxy-benzyloxy)-2-methyl-hexanoyl]-4-methyl-5-phenyl-oxazolidin-2-one

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Chemical Property of (4R,5S)-3-[(2R,3S)-6-Benzyloxy-3-(4-methoxy-benzyloxy)-2-methyl-hexanoyl]-4-methyl-5-phenyl-oxazolidin-2-one

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Technology Process of (4R,5S)-3-[(2R,3S)-6-Benzyloxy-3-(4-methoxy-benzyloxy)-2-methyl-hexanoyl]-4-methyl-5-phenyl-oxazolidin-2-one

There total 3 articles about (4R,5S)-3-[(2R,3S)-6-Benzyloxy-3-(4-methoxy-benzyloxy)-2-methyl-hexanoyl]-4-methyl-5-phenyl-oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5470-84-8
4-benzyloxybutanal

: 852244-90-7
(4R,5S)-3-[(2R,3S)-6-Benzyloxy-3-(4-methoxy-benzyloxy)-2-methyl-hexanoyl]-4-methyl-5-phenyl-oxazolidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: Et₃N; dibutylboron triflate / CH₂Cl₂ / 1 h / 0 °C

1.2: CH₂Cl₂ / 2 h / -78 - 20 °C

1.3: 83 percent / H₂O₂ / H₂O; methanol / 1 h / 0 °C

2.1: camphorsulfonic acid / CH₂Cl₂ / 24 h / 20 °C

With di-n-butylboryl trifluoromethanesulfonate; camphor-10-sulfonic acid; triethylamine; In dichloromethane; 1.2: aldol condensation;
DOI:10.1021/ol0504291

Reference yield:

: 852244-89-4
(4R,5S)-3-((2R,3S)-6-Benzyloxy-3-hydroxy-2-methyl-hexanoyl)-4-methyl-5-phenyl-oxazolidin-2-one

: 89238-99-3
O-(4-methoxybenzyl)-trichloroacetimidate

: 852244-90-7
(4R,5S)-3-[(2R,3S)-6-Benzyloxy-3-(4-methoxy-benzyloxy)-2-methyl-hexanoyl]-4-methyl-5-phenyl-oxazolidin-2-one

Guidance literature:: With camphor-10-sulfonic acid; In dichloromethane; at 20 ℃; for 24h;
DOI:10.1021/ol0504291

Reference yield:

: 77877-20-4
(4R,5S)-4-methyl-5-phenyl-3-propionyloxazolidin-2-one

: 852244-90-7
(4R,5S)-3-[(2R,3S)-6-Benzyloxy-3-(4-methoxy-benzyloxy)-2-methyl-hexanoyl]-4-methyl-5-phenyl-oxazolidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: Et₃N; dibutylboron triflate / CH₂Cl₂ / 1 h / 0 °C

1.2: CH₂Cl₂ / 2 h / -78 - 20 °C

1.3: 83 percent / H₂O₂ / H₂O; methanol / 1 h / 0 °C

2.1: camphorsulfonic acid / CH₂Cl₂ / 24 h / 20 °C

With di-n-butylboryl trifluoromethanesulfonate; camphor-10-sulfonic acid; triethylamine; In dichloromethane; 1.2: aldol condensation;
DOI:10.1021/ol0504291