2-(1-(2-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)acetic acid

Base Information

Chemical Name:2-(1-(2-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)acetic acid
CAS No.:1033586-41-2
Molecular Formula:C₁₂H₈ClF₃N₂O₂
Molecular Weight:304.656
Hs Code.:

Synonyms:2-(1-(2-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)acetic acid

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Chemical Property of 2-(1-(2-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)acetic acid

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Technology Process of 2-(1-(2-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)acetic acid

There total 9 articles about 2-(1-(2-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₂H₇ClF₃N₂O₂^(1-)*K⁽¹⁺⁾

: 1033586-41-2
2-(1-(2-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)acetic acid

Guidance literature:: With hydrogenchloride; In water; ethyl acetate;

Reference yield:

: 437711-25-6
1-(2-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxylic acid

: 1033586-41-2
2-(1-(2-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)acetic acid

Guidance literature:: Multi-step reaction with 6 steps

1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 3 h / 20 °C

2: diisobutylaluminium hydride / tetrahydrofuran / 1.5 h / -10 - 20 °C

3: dibromotriphenylphosphorane / dichloromethane / 2 h / 20 °C

4: N,N-dimethyl-formamide / 4 h / 50 °C

5: potassium hydroxide; ethanol / 17 h / Heating / reflux

6: hydrogenchloride / water; ethyl acetate

With hydrogenchloride; dmap; potassium hydroxide; ethanol; diisobutylaluminium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dibromotriphenylphosphorane; In tetrahydrofuran; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 1033586-28-5
5-bromomethyl-1-(2-chlorophenyl)-3-trifluoromethyl-1H-pyrazole

: 1033586-41-2
2-(1-(2-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: N,N-dimethyl-formamide / 4 h / 50 °C

2: potassium hydroxide; ethanol / 17 h / Heating / reflux

3: hydrogenchloride / water; ethyl acetate

With hydrogenchloride; potassium hydroxide; ethanol; In water; ethyl acetate; N,N-dimethyl-formamide;