2-[2-(2-chlorophenyl)-5-trifluoromethyl-2H-pyrazol-3-yl]-N-quinolin-6-ylacetamide

Base Information

Chemical Name:2-[2-(2-chlorophenyl)-5-trifluoromethyl-2H-pyrazol-3-yl]-N-quinolin-6-ylacetamide
CAS No.:1033575-66-4
Molecular Formula:C₂₁H₁₄ClF₃N₄O
Molecular Weight:430.817
Hs Code.:

Synonyms:2-[2-(2-chlorophenyl)-5-trifluoromethyl-2H-pyrazol-3-yl]-N-quinolin-6-ylacetamide

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Chemical Property of 2-[2-(2-chlorophenyl)-5-trifluoromethyl-2H-pyrazol-3-yl]-N-quinolin-6-ylacetamide

Chemical Property:

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Technology Process of 2-[2-(2-chlorophenyl)-5-trifluoromethyl-2H-pyrazol-3-yl]-N-quinolin-6-ylacetamide

There total 11 articles about 2-[2-(2-chlorophenyl)-5-trifluoromethyl-2H-pyrazol-3-yl]-N-quinolin-6-ylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 580-15-4
6-aminoquinoline

: 1033586-96-7
C₁₂H₇Cl₂F₃N₂O

: 1033575-66-4
2-[2-(2-chlorophenyl)-5-trifluoromethyl-2H-pyrazol-3-yl]-N-quinolin-6-ylacetamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 60 ℃;

Reference yield:

: 437711-25-6
1-(2-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxylic acid

: 1033575-66-4
2-[2-(2-chlorophenyl)-5-trifluoromethyl-2H-pyrazol-3-yl]-N-quinolin-6-ylacetamide

Guidance literature:: Multi-step reaction with 8 steps

1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 3 h / 20 °C

2: diisobutylaluminium hydride / tetrahydrofuran / 1.5 h / -10 - 20 °C

3: dibromotriphenylphosphorane / dichloromethane / 2 h / 20 °C

4: N,N-dimethyl-formamide / 4 h / 50 °C

5: potassium hydroxide; ethanol / 17 h / Heating / reflux

6: hydrogenchloride / water; ethyl acetate

7: oxalyl dichloride / N,N-dimethyl-formamide / tetrahydrofuran / 0.5 h

8: N-ethyl-N,N-diisopropylamine / acetonitrile / 60 °C

With hydrogenchloride; dmap; potassium hydroxide; oxalyl dichloride; ethanol; diisobutylaluminium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; dibromotriphenylphosphorane; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 437711-24-5
1-(2-Chlorophenyl)-5-(2-furanyl)-3-(trifluoromethyl)-1H-pyrazole

: 1033575-66-4
2-[2-(2-chlorophenyl)-5-trifluoromethyl-2H-pyrazol-3-yl]-N-quinolin-6-ylacetamide

Guidance literature:: Multi-step reaction with 10 steps

1: sodium chlorite; sodium dihydrogenphosphate / water; acetonitrile / 42 h / 0 - 20 °C

2: hydrogenchloride / dichloromethane; water

3: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 3 h / 20 °C

4: diisobutylaluminium hydride / tetrahydrofuran / 1.5 h / -10 - 20 °C

5: dibromotriphenylphosphorane / dichloromethane / 2 h / 20 °C

6: N,N-dimethyl-formamide / 4 h / 50 °C

7: potassium hydroxide; ethanol / 17 h / Heating / reflux

8: hydrogenchloride / water; ethyl acetate

9: oxalyl dichloride / N,N-dimethyl-formamide / tetrahydrofuran / 0.5 h

10: N-ethyl-N,N-diisopropylamine / acetonitrile / 60 °C

With hydrogenchloride; dmap; potassium hydroxide; sodium chlorite; sodium dihydrogenphosphate; oxalyl dichloride; ethanol; diisobutylaluminium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; dibromotriphenylphosphorane; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;