ethyl[2R-(R,R)]-2-hydroxy-4-oxo-3-benzyloxy-4-[(benzyloxy)-amino]-butanoate

Base Information

Chemical Name:ethyl[2R-(R*,R*)]-2-hydroxy-4-oxo-3-benzyloxy-4-[(benzyloxy)-amino]-butanoate
CAS No.:104211-05-4
Molecular Formula:C₂₀H₂₃NO₆
Molecular Weight:373.406
Hs Code.:

Synonyms:ethyl[2R-(R*,R*)]-2-hydroxy-4-oxo-3-benzyloxy-4-[(benzyloxy)-amino]-butanoate

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Chemical Property of ethyl[2R-(R*,R*)]-2-hydroxy-4-oxo-3-benzyloxy-4-[(benzyloxy)-amino]-butanoate

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Technology Process of ethyl[2R-(R*,R*)]-2-hydroxy-4-oxo-3-benzyloxy-4-[(benzyloxy)-amino]-butanoate

There total 5 articles about ethyl[2R-(R*,R*)]-2-hydroxy-4-oxo-3-benzyloxy-4-[(benzyloxy)-amino]-butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 104333-85-9
O-benzylidene tartrate

: 104211-05-4
ethyl[2R-(R*,R*)]-2-hydroxy-4-oxo-3-benzyloxy-4-[(benzyloxy)-amino]-butanoate

Guidance literature:: Multi-step reaction with 3 steps

1: 85 percent / sodium cyanoborohydride, HCl / acetonitrile; diethyl ether / 1 h / Ambient temperature

2: K₂CO₃ / dioxane; H₂O

3: 1-ethyl-3-(dimethylamino)propylcarbodiimide hydrochloride / H₂O; tetrahydrofuran / 1 h / Ambient temperature; pH = 4,5

With hydrogenchloride; sodium cyanoborohydride; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; 1,4-dioxane; diethyl ether; water; acetonitrile;
DOI:10.1016/S0040-4039(00)83934-9

Reference yield:

: 119770-87-5,104211-01-0
(2R,3R)-diethyl 2-(benzyloxy)-3-hydroxysuccinate

: 104211-05-4
ethyl[2R-(R*,R*)]-2-hydroxy-4-oxo-3-benzyloxy-4-[(benzyloxy)-amino]-butanoate

Guidance literature:: Multi-step reaction with 2 steps

1: K₂CO₃ / dioxane; H₂O

2: 1-ethyl-3-(dimethylamino)propylcarbodiimide hydrochloride / H₂O; tetrahydrofuran / 1 h / Ambient temperature; pH = 4,5

With potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; 1,4-dioxane; water;
DOI:10.1016/S0040-4039(00)83934-9

Reference yield:

: 35572-31-7
(4R,5R)-2-Phenyl-1,3-dioxolan-4,5-dicarbonsaeure-diethylester

: 104211-05-4
ethyl[2R-(R*,R*)]-2-hydroxy-4-oxo-3-benzyloxy-4-[(benzyloxy)-amino]-butanoate

Guidance literature:: Multi-step reaction with 2 steps

1: 77 percent / NaCNBH₃, HCl / acetonitrile; diethyl ether / 1 h / Ambient temperature

2: 1.) K₂CO₃; 2.) 1-ethyl-3-(dimethylamino)propylcarbodiimide hydrochloride, HCl / 1.) dioxane-water, r.t., 5 h; 2.) water, 30 min

With hydrogenchloride; sodium cyanoborohydride; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In diethyl ether; acetonitrile;
DOI:10.1016/S0040-4020(01)81921-9