4-chloro-1-(2-methoxyethyl)-7-trifluoromethoxy-1H-indole-3-carboxylic acid

Base Information

Chemical Name:4-chloro-1-(2-methoxyethyl)-7-trifluoromethoxy-1H-indole-3-carboxylic acid
CAS No.:1268052-52-3
Molecular Formula:C₁₃H₁₁ClF₃NO₄
Molecular Weight:337.683
Hs Code.:

Synonyms:4-chloro-1-(2-methoxyethyl)-7-trifluoromethoxy-1H-indole-3-carboxylic acid

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Chemical Property of 4-chloro-1-(2-methoxyethyl)-7-trifluoromethoxy-1H-indole-3-carboxylic acid

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Technology Process of 4-chloro-1-(2-methoxyethyl)-7-trifluoromethoxy-1H-indole-3-carboxylic acid

There total 4 articles about 4-chloro-1-(2-methoxyethyl)-7-trifluoromethoxy-1H-indole-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1268052-50-1
1-[4-chloro-1-(2-methoxyethyl)-7-trifluoromethoxy-1H-indol-3-yl]-2,2,2-trifluoroethanone

: 1268052-52-3
4-chloro-1-(2-methoxyethyl)-7-trifluoromethoxy-1H-indole-3-carboxylic acid

Guidance literature:: 1-[4-chloro-1-(2-methoxyethyl)-7-trifluoromethoxy-1H-indol-3-yl]-2,2,2-trifluoroethanone; With sodium hydroxide; In methanol; at 20 - 80 ℃;

With hydrogenchloride; In water; pH=1;

Reference yield:

: 461-81-4
1-chloro-4-(trifluoromethoxy)benzene

: 1268052-52-3
4-chloro-1-(2-methoxyethyl)-7-trifluoromethoxy-1H-indole-3-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: nitric acid; sulfuric acid / 1.08 h / 0 °C

1.2: 1.17 h / -78 °C

2.1: potassium hydroxide / dimethyl sulfoxide / 0.08 h / 20 °C

2.2: 20 °C

3.1: N,N-dimethyl-formamide / 20 - 60 °C

4.1: sodium hydroxide / methanol / 20 - 80 °C

4.2: pH 1

With sulfuric acid; nitric acid; potassium hydroxide; sodium hydroxide; In methanol; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 1268052-48-7
4-chloro-7-trifluoromethoxy-1H-indole

: 1268052-52-3
4-chloro-1-(2-methoxyethyl)-7-trifluoromethoxy-1H-indole-3-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium hydroxide / dimethyl sulfoxide / 0.08 h / 20 °C

1.2: 20 °C

2.1: N,N-dimethyl-formamide / 20 - 60 °C

3.1: sodium hydroxide / methanol / 20 - 80 °C

3.2: pH 1

With potassium hydroxide; sodium hydroxide; In methanol; dimethyl sulfoxide; N,N-dimethyl-formamide;