N-(3-{1-[4-chloro-1-(2-methoxyethyl)-7-trifluoromethoxy-1H-indole-3-carbonyl]piperidin-4-yl}-4-fluorobenzyl)-2,2,2-trifluoroacetamide

Base Information

Chemical Name:N-(3-{1-[4-chloro-1-(2-methoxyethyl)-7-trifluoromethoxy-1H-indole-3-carbonyl]piperidin-4-yl}-4-fluorobenzyl)-2,2,2-trifluoroacetamide
CAS No.:1268052-55-6
Molecular Formula:C₂₇H₂₅ClF₇N₃O₄
Molecular Weight:623.955
Hs Code.:

Synonyms:N-(3-{1-[4-chloro-1-(2-methoxyethyl)-7-trifluoromethoxy-1H-indole-3-carbonyl]piperidin-4-yl}-4-fluorobenzyl)-2,2,2-trifluoroacetamide

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Chemical Property of N-(3-{1-[4-chloro-1-(2-methoxyethyl)-7-trifluoromethoxy-1H-indole-3-carbonyl]piperidin-4-yl}-4-fluorobenzyl)-2,2,2-trifluoroacetamide

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Technology Process of N-(3-{1-[4-chloro-1-(2-methoxyethyl)-7-trifluoromethoxy-1H-indole-3-carbonyl]piperidin-4-yl}-4-fluorobenzyl)-2,2,2-trifluoroacetamide

There total 8 articles about N-(3-{1-[4-chloro-1-(2-methoxyethyl)-7-trifluoromethoxy-1H-indole-3-carbonyl]piperidin-4-yl}-4-fluorobenzyl)-2,2,2-trifluoroacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 1067427-53-5
2,2,2-trifluoro-N-(4-fluoro-3-piperidin-4-yl-benzyl)acetamide hydrochloride

: 1268052-52-3
4-chloro-1-(2-methoxyethyl)-7-trifluoromethoxy-1H-indole-3-carboxylic acid

: 1268052-55-6
N-(3-{1-[4-chloro-1-(2-methoxyethyl)-7-trifluoromethoxy-1H-indole-3-carbonyl]piperidin-4-yl}-4-fluorobenzyl)-2,2,2-trifluoroacetamide

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 20 ℃;

Reference yield:

: 1692-15-5
4-pyridylboronic acid

: 1268052-55-6
N-(3-{1-[4-chloro-1-(2-methoxyethyl)-7-trifluoromethoxy-1H-indole-3-carbonyl]piperidin-4-yl}-4-fluorobenzyl)-2,2,2-trifluoroacetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydrogencarbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / isopropyl alcohol; water / 20 - 80 °C / Inert atmosphere

1.2: 0.5 h / 20 °C

2.1: hydrogen / platinum on carbon / methanol / 48 h / 20 °C / 517.16 - 3102.97 Torr

3.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

With hydrogen; sodium hydrogencarbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; platinum on carbon; In methanol; dichloromethane; water; isopropyl alcohol;

Reference yield:

: 1208977-19-8
2,2,2-trifluoro-N-(4-fluoro-3-pyridin-4-yl-benzyl)-acetamide hydrochloride

: 1268052-55-6
N-(3-{1-[4-chloro-1-(2-methoxyethyl)-7-trifluoromethoxy-1H-indole-3-carbonyl]piperidin-4-yl}-4-fluorobenzyl)-2,2,2-trifluoroacetamide

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen / platinum on carbon / methanol / 48 h / 20 °C / 517.16 - 3102.97 Torr

2: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

With hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; platinum on carbon; In methanol; dichloromethane;