(4R,5S)-4-(iodoethynyl)-5-[(4-methoxyphenoxy)methyl]-1,3-dioxolan-2-one

Base Information

Chemical Name:(4R,5S)-4-(iodoethynyl)-5-[(4-methoxyphenoxy)methyl]-1,3-dioxolan-2-one
CAS No.:1439510-68-5
Molecular Formula:C₁₃H₁₁IO₅
Molecular Weight:374.132
Hs Code.:

Synonyms:(4R,5S)-4-(iodoethynyl)-5-[(4-methoxyphenoxy)methyl]-1,3-dioxolan-2-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (4R,5S)-4-(iodoethynyl)-5-[(4-methoxyphenoxy)methyl]-1,3-dioxolan-2-one

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Technology Process of (4R,5S)-4-(iodoethynyl)-5-[(4-methoxyphenoxy)methyl]-1,3-dioxolan-2-one

There total 5 articles about (4R,5S)-4-(iodoethynyl)-5-[(4-methoxyphenoxy)methyl]-1,3-dioxolan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1439510-61-8
(4R,5S)-4-ethynyl-5-[(4-methoxyphenoxy)methyl]-1,3-dioxolan-2-one

: 1439510-68-5
(4R,5S)-4-(iodoethynyl)-5-[(4-methoxyphenoxy)methyl]-1,3-dioxolan-2-one

Guidance literature:: With N-iodo-succinimide; silver nitrate; In acetone; at 20 ℃; for 0.25h; Inert atmosphere;
DOI:10.1021/ol401231y

Reference yield:

: 1439510-53-8
(4R,5S)-4-ethynyl-5-[(4-methoxyphenoxy)methyl]-2,2-dimethyl-1,3-dioxolane

: 1439510-68-5
(4R,5S)-4-(iodoethynyl)-5-[(4-methoxyphenoxy)methyl]-1,3-dioxolan-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: toluene-4-sulfonic acid / methanol / 17 h / 20 °C / Inert atmosphere

2: pyridine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

3: N-iodo-succinimide; silver nitrate / acetone / 0.25 h / 20 °C / Inert atmosphere

With pyridine; N-iodo-succinimide; toluene-4-sulfonic acid; silver nitrate; In methanol; dichloromethane; acetone;
DOI:10.1021/ol401231y

Reference yield:

: 127305-55-9
[(4S,5R)-5-ethynyl-2,2-dimethyl-1,3-dioxolan-4-yl]methanol

: 1439510-68-5
(4R,5S)-4-(iodoethynyl)-5-[(4-methoxyphenoxy)methyl]-1,3-dioxolan-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: triphenylphosphine; diethylazodicarboxylate / toluene / 1 h / 0 - 70 °C / Inert atmosphere

2: toluene-4-sulfonic acid / methanol / 17 h / 20 °C / Inert atmosphere

3: pyridine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

4: N-iodo-succinimide; silver nitrate / acetone / 0.25 h / 20 °C / Inert atmosphere

With pyridine; N-iodo-succinimide; toluene-4-sulfonic acid; silver nitrate; triphenylphosphine; diethylazodicarboxylate; In methanol; dichloromethane; acetone; toluene; 1: |Mitsunobu Displacement;
DOI:10.1021/ol401231y