ethyl (2-acetoxymethyl-3,4-dimethoxyphenyl)-N-[(2,2-dimethoxyethyl)-N-(4-toluenesulfonyl)amino]acetate

Base Information

Chemical Name:ethyl (2-acetoxymethyl-3,4-dimethoxyphenyl)-N-[(2,2-dimethoxyethyl)-N-(4-toluenesulfonyl)amino]acetate
CAS No.:293731-05-2
Molecular Formula:C₂₆H₃₅NO₁₀S
Molecular Weight:553.631
Hs Code.:

Synonyms:ethyl (2-acetoxymethyl-3,4-dimethoxyphenyl)-N-[(2,2-dimethoxyethyl)-N-(4-toluenesulfonyl)amino]acetate

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Chemical Property of ethyl (2-acetoxymethyl-3,4-dimethoxyphenyl)-N-[(2,2-dimethoxyethyl)-N-(4-toluenesulfonyl)amino]acetate

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Technology Process of ethyl (2-acetoxymethyl-3,4-dimethoxyphenyl)-N-[(2,2-dimethoxyethyl)-N-(4-toluenesulfonyl)amino]acetate

There total 7 articles about ethyl (2-acetoxymethyl-3,4-dimethoxyphenyl)-N-[(2,2-dimethoxyethyl)-N-(4-toluenesulfonyl)amino]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 98-59-9
p-toluenesulfonyl chloride

: 338446-36-9
(2-acetoxymethyl-3,4-dimethoxy-phenyl)-(2,2-dimethoxy-ethylamino)-acetic acid ethyl ester

: 293731-05-2
ethyl (2-acetoxymethyl-3,4-dimethoxyphenyl)-N-[(2,2-dimethoxyethyl)-N-(4-toluenesulfonyl)amino]acetate

Guidance literature:: With triethylamine; In chloroform; at 20 ℃; for 24h;
DOI:10.3987/com-00-9099

Reference yield:

: 4463-33-6
1,2-dimethoxy-3-methylbenzene

: 293731-05-2
ethyl (2-acetoxymethyl-3,4-dimethoxyphenyl)-N-[(2,2-dimethoxyethyl)-N-(4-toluenesulfonyl)amino]acetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: 94 percent / AlCl₃ / CH₂Cl₂ / 20 °C

2.1: 90 percent / NBS; AIBN / CCl₄ / 1.5 h / Heating

3.1: 88 percent / sodium acetate / hexamethylphosphoric acid triamide / 24 h / 20 °C

4.1: glacial acetic acid / ethanol / 1 h / 20 °C

4.2: 52 percent / sodium cyanoborohydride / 20 °C

5.1: 81 percent / triethylamine / CHCl₃ / 24 h / 20 °C

With N-Bromosuccinimide; aluminium trichloride; 2,2'-azobis(isobutyronitrile); sodium acetate; acetic acid; triethylamine; In tetrachloromethane; N,N,N,N,N,N-hexamethylphosphoric triamide; ethanol; dichloromethane; chloroform; 1.1: Friedel-Crafts reaction;
DOI:10.3987/com-00-9099

Reference yield:

: 293731-03-0
(3,4-dimethoxy-2-methyl-phenyl)-oxo-acetic acid ethyl ester

: 293731-05-2
ethyl (2-acetoxymethyl-3,4-dimethoxyphenyl)-N-[(2,2-dimethoxyethyl)-N-(4-toluenesulfonyl)amino]acetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 90 percent / NBS; AIBN / CCl₄ / 1.5 h / Heating

2.1: 88 percent / sodium acetate / hexamethylphosphoric acid triamide / 24 h / 20 °C

3.1: glacial acetic acid / ethanol / 1 h / 20 °C

3.2: 52 percent / sodium cyanoborohydride / 20 °C

4.1: 81 percent / triethylamine / CHCl₃ / 24 h / 20 °C

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); sodium acetate; acetic acid; triethylamine; In tetrachloromethane; N,N,N,N,N,N-hexamethylphosphoric triamide; ethanol; chloroform;
DOI:10.3987/com-00-9099