5-(3-chlorophenoxy)-1,3-dimethyl-1H-pyrazole-4-carbaldehyde

Base Information

• Chemical Name: 5-(3-chlorophenoxy)-1,3-dimethyl-1H-pyrazole-4-carbaldehyde
• CAS No.: 109925-12-4
• Molecular Formula: C₁₂H₁₁ClN₂O₂
• Molecular Weight: 250.685
• Hs Code.: 2933199090
• Mol file: 109925-12-4.mol

Synonyms:5-(3-chlorophenoxy)-1,3-dimethyl-1H-pyrazole-4-carbaldehyde

Chemical Property of 5-(3-chlorophenoxy)-1,3-dimethyl-1H-pyrazole-4-carbaldehyde

Chemical Property:

• Melting Point: 87-89°C

Purity/Quality:

98%min ^*data from raw suppliers

5-(3-Chlorophenoxy)-1,3-dimethyl-1H-pyrazole-4-carbaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(3-chlorophenoxy)-1,3-dimethyl-1H-pyrazole-4-carbaldehyde

There total 3 articles about 5-(3-chlorophenoxy)-1,3-dimethyl-1H-pyrazole-4-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-monochlorophenol (108-43-0) + 5-chloro-4-formyl-1,3-dimethylpyrazole (27006-76-4) → 5-(3-chlorophenoxy)-1,3-dimethyl-1H-pyrazole-4-carbaldehyde (109925-12-4)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 110 ℃; for 16h; Inert atmosphere;

DOI:10.1016/j.bmcl.2012.12.076

Reference yield:

1,3-dimethyl-1H-pyrazol-5-ol (5203-77-0) → 5-(3-chlorophenoxy)-1,3-dimethyl-1H-pyrazole-4-carbaldehyde (109925-12-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: trichlorophosphate / 0.33 h / 20 °C

1.2: 80 °C

2.1: N-benzyl-N,N,N-triethylammonium chloride; potassium hydroxide / acetonitrile / Reflux

With N-benzyl-N,N,N-triethylammonium chloride; potassium hydroxide; trichlorophosphate; In acetonitrile; 1.2: |Vilsmeier-Haack Formylation;

DOI:10.2174/1570180813666160711155752

Reference yield:

1,3-dimethyl-5-pyrazolone (2749-59-9) → 5-(3-chlorophenoxy)-1,3-dimethyl-1H-pyrazole-4-carbaldehyde (109925-12-4)

Guidance literature:

Multi-step reaction with 2 steps

1: trichlorophosphate / 5 h / 100 °C

2: sodium hydroxide / ethanol; dimethyl sulfoxide / 100 °C

With sodium hydroxide; trichlorophosphate; In ethanol; dimethyl sulfoxide;

DOI:10.1016/j.ejmech.2019.01.070

upstream raw materials:

3-monochlorophenol

5-chloro-4-formyl-1,3-dimethylpyrazole

1,3-dimethyl-1H-pyrazol-5-ol

1,3-dimethyl-5-pyrazolone

Downstream raw materials:

C₂₂H₂₃ClN₄O₂

C₁₂H₁₁ClN₂O₃