Clenbuterol hydrochloride

Base Information

• Chemical Name: Clenbuterol hydrochloride
• CAS No.: 21898-19-1
• Deprecated CAS: 53144-57-3,69930-61-6
• Molecular Formula: C12H18Cl2N2O^.HCl
• Molecular Weight: 313.655
• Hs Code.: 29221990
• European Community (EC) Number: 244-643-7
• NSC Number: 758633
• UNII: GOR5747GWU
• DSSTox Substance ID: DTXSID60944496
• Wikidata: Q27114305
• NCI Thesaurus Code: C87473
• RXCUI: 235955
• ChEMBL ID: CHEMBL1330729
• Mol file: 21898-19-1.mol

Synonyms:Clenbuterol;NAB 365;NAB-365;NAB365;Planipart

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Chemical Property of Clenbuterol hydrochloride

Chemical Property:

• Appearance/Colour: Colourless microcrystalline powder
• Melting Point: 174-175.5 °C
• Boiling Point: 404.9 °C at 760 mmHg
• Flash Point: 198.7 °C
• PSA: 58.28000
• Density: 1.25g/cm3
• LogP: 4.77120
• Storage Temp.: 2-8°C
• Solubility.: Soluble in water and in ethanol (96 per cent), slightly soluble in acetone.
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 312.056296
• Heavy Atom Count: 18
• Complexity: 233

Purity/Quality:

Safty Information:

• Pictogram(s): T
• Hazard Codes: T,F
• Statements: 25-39/23/24/25-23/24/25-11
• Safety Statements: 22-36/37/39-45-36/37-16

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)NCC(C1=CC(=C(C(=C1)Cl)N)Cl)O.Cl
• Recent ClinicalTrials: Human Beta-2 Adrenergic Stimulation and Muscle Glucose Uptake
• Recent EU Clinical Trials: A Phase II, Randomized, Placebo-Controlled, Double-Blind, Crossover, Study of the Pharmacodynamic Effects of CST-103 co-administered with CST-107 on the Central Nervous System in Subjects with Neurodegenerative Disorders
• Uses: Clenbuterol hydrochloride can be used for the prevention and treatment of bronchial asthma, chronic bronchitis, emphysema-accompanied bronchial spasms caused by bronchitis.Clenbuterol hydrochloride?is a kind of β2-adrenergic receptor agonists and can be used as bronchodilators. Bronchodilatator;Beta adrenergic agonist Substituted phenylethanolamine with β2 sympathomimetic activity. Bronchodilator. A β-Agonist which can be used as a growth promoter in farm animals. decongestant bronchodilator Antiasthmatic Substituted phenylethanolamine with 2 sympathomimetic activity. Bronchodilator

Technology Process of Clenbuterol hydrochloride

There total 3 articles about Clenbuterol hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C12H14Cl2N2O → clenbuterol hydrochloride (21898-19-1,50310-83-3)

Guidance literature:

C₁₂H₁₄Cl₂N₂O; With methanol; sodium tetrahydroborate; In water; at 0 - 25 ℃; for 2.25h; Green chemistry;

With hydrogenchloride; In isopropyl alcohol; at 10 - 40 ℃; for 2h; pH=5 - 6; Green chemistry;

Reference yield:

1-(4-amino-3,5-dichlorophenyl)-1-ethanone (37148-48-4) → clenbuterol hydrochloride (21898-19-1,50310-83-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: selenium(IV) oxide / tetrahydrofuran / 6 h / 45 - 50 °C / Green chemistry

2.1: tetrahydrofuran; toluene / 2.25 h / 40 - 45 °C / Green chemistry

3.1: methanol; sodium tetrahydroborate / water / 2.25 h / 0 - 25 °C / Green chemistry

3.2: 2 h / 10 - 40 °C / pH 5 - 6 / Green chemistry

With methanol; selenium(IV) oxide; sodium tetrahydroborate; In tetrahydrofuran; water; toluene;

Reference yield:

→ clenbuterol hydrochloride (21898-19-1,50310-83-3)

Guidance literature:

upstream raw materials:

1-(4-amino-3,5-dichlorophenyl)-1-ethanone

Refernces

• 1、 -. "SUSTAINED RELEASING PATCH". . . Retrieved 2008/06/13.