Nile Blue chloride

Base Information

• Chemical Name: Nile Blue chloride
• CAS No.: 2381-85-3
• Deprecated CAS: 105480-57-7,114567-73-6,20517-93-5,89168-53-6,298209-62-8,299426-03-2,348637-62-7,415902-65-7,832733-89-8,874358-59-5,1026018-39-2,1026232-05-2,1063750-19-5,927191-06-8,898282-92-3
• Molecular Formula: C20H20 N3 O . Cl
• Molecular Weight: 353.851
• Hs Code.: 32041990
• European Community (EC) Number: 219-181-4
• NSC Number: 146184
• UNII: E58RL8T2X3
• DSSTox Substance ID: DTXSID40883834
• Wikipedia: Nile_blue
• Wikidata: Q27123279
• ChEMBL ID: CHEMBL407862
• Mol file: 2381-85-3.mol

Synonyms:Cresyl Fast Violet;Nile Blue;nile blue A perchlorate;Nile Blue perchlorate;nile blue sulfate;Nile Blue tetrafluoroborate

Chemical Property of Nile Blue chloride

Chemical Property:

• Appearance/Colour: crystalline solid
• Melting Point: >250°C
• Boiling Point: 487.9°Cat760mmHg
• PKA: 9.7(at 25℃)
• Flash Point: 248.8°C
• PSA: 55.06000
• Density: g/cm³
• LogP: 1.06520
• Solubility.: Solubility Soluble in water, ethanol
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 353.1294900
• Heavy Atom Count: 25
• Complexity: 625

Purity/Quality:

98%,99%, ^*data from raw suppliers

Nile Blue Chloride ^*data from reagent suppliers

Safty Information:

• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Dyes -> Azine Dyes
• Canonical SMILES: CC[N+](=C1C=CC2=NC3=C(C=C(C4=CC=CC=C43)N)OC2=C1)CC.[Cl-]
• Uses: Nile Blue chloride is a histological and lipid stain.

Technology Process of Nile Blue chloride

There total 5 articles about Nile Blue chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C24H24N3O3(1+)*Cl(1-) → 5-amino-9-(diethylamino)benzo[a]phenoxazin-7-ium chloride (2381-85-3,89168-53-6)

Guidance literature:

With dichlorobis(tri(2-furyl)phosphine)palladium(II); In aq. phosphate buffer; dimethyl sulfoxide; at 20 ℃; pH=7.4; Reagent/catalyst;

DOI:10.1002/cplu.202000477

Reference yield:

C37H38N3O7(1+)*Cl(1-) → 5-amino-9-(diethylamino)benzo[a]phenoxazin-7-ium chloride (2381-85-3,89168-53-6)

Guidance literature:

With 3,6-di(2'-pyridyl)-1,2,4,5-tetrazine; In aq. buffer; at 37 ℃; pH=7.4;

DOI:10.1002/cbic.201600560

Reference yield:

[1,4]naphthoquinone-bis-chlorimin (23939-67-5) + 3-diethylaminophenol (91-68-9) → 5-amino-9-(diethylamino)benzo[a]phenoxazin-7-ium chloride (2381-85-3,89168-53-6)

Guidance literature:

With methanol; at 50 - 60 ℃;

upstream raw materials:

2-Hydroxy-4-imino-4H-naphthalen-1-one

2-amino-5-(diethylamino)phenol dihydrochloride

[1,4]naphthoquinone-bis-chlorimin

3-diethylaminophenol

Downstream raw materials:

1,3-diisopropylurea

Refernces

• 1、 Neumann, Kevin,Jain, Sarthak,Gambardella, Alessia,Walker, Sarah E.,Valero, Elsa,Lilienkampf, Annamaria,Bradley, Mark. "Tetrazine-Responsive Self-immolative Linkers". . p. 91 - 95. Retrieved 2017/01/07.