(R)-1-((2-(2,4-difluorophenyl)-4-methylenetetrahydrofuran-2-yl)methyl)-1H-1,2,4-triazole

Base Information

• Chemical Name: (R)-1-((2-(2,4-difluorophenyl)-4-methylenetetrahydrofuran-2-yl)methyl)-1H-1,2,4-triazole
• CAS No.: 1370190-85-4
• Molecular Formula: C₁₄H₁₃F₂N₃O
• Molecular Weight: 277.274
• Mol file: 1370190-85-4.mol

Synonyms:(R)-1-((2-(2,4-difluorophenyl)-4-methylenetetrahydrofuran-2-yl)methyl)-1H-1,2,4-triazole

Chemical Property of (R)-1-((2-(2,4-difluorophenyl)-4-methylenetetrahydrofuran-2-yl)methyl)-1H-1,2,4-triazole

Chemical Property:

Purity/Quality:

NLT 98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-1-((2-(2,4-difluorophenyl)-4-methylenetetrahydrofuran-2-yl)methyl)-1H-1,2,4-triazole

There total 3 articles about (R)-1-((2-(2,4-difluorophenyl)-4-methylenetetrahydrofuran-2-yl)methyl)-1H-1,2,4-triazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl 4-(4-hydroxy-3-methylphenyl)piperazine-1-carboxylate + (2R-cis)-2-(2,4-difluorophenyl)-4-[[(4-methylphenyl)sulfonyloxy]methyl]-2-[(1H-1,2,4-triazol-1-yl)methyl]tetrahydrofuran (149809-43-8) → (R)-1-((2-(2,4-difluorophenyl)-4-methylenetetrahydrofuran-2-yl)methyl)-1H-1,2,4-triazole (1370190-85-4) + C30H37F2N5O4

Guidance literature:

tert-butyl 4-(4-hydroxy-3-methylphenyl)piperazine-1-carboxylate; With sodium hydroxide; In dimethyl sulfoxide; at 20 ℃; for 0.166667h;

(2R-cis)-2-(2,4-difluorophenyl)-4-[[(4-methylphenyl)sulfonyloxy]methyl]-2-[(1H-1,2,4-triazol-1-yl)methyl]tetrahydrofuran; In dimethyl sulfoxide; at 30 ℃; for 18h;

Reference yield:

((3S,5R)-5-((1H-1,2,4-triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methyl 4-methylbenzenesulfonate + tert-butyl 4-(4-hydroxyphenyl)piperazine-1-carboxylate (158985-25-2) → (R)-1-((2-(2,4-difluorophenyl)-4-methylenetetrahydrofuran-2-yl)methyl)-1H-1,2,4-triazole (1370190-85-4) + C29H35F2N5O4

Guidance literature:

tert-butyl 4-(4-hydroxyphenyl)piperazine-1-carboxylate; With sodium hydroxide; In water; dimethyl sulfoxide; at 20 ℃; for 0.5h;

((3S,5R)-5-((1H-1,2,4-triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methyl 4-methylbenzenesulfonate; In water; dimethyl sulfoxide; at 40 ℃; for 18h;

Reference yield:

[2-(acetoxymethyl)prop-2-enyl]trimethylsilane (72047-94-0) + 1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone (86404-63-9) → (R)-1-((2-(2,4-difluorophenyl)-4-methylenetetrahydrofuran-2-yl)methyl)-1H-1,2,4-triazole (1370190-85-4) + (S)-1-((2-(2,4-difluorophenyl)-4-methylenetetrahydrofuran-2-yl)methyl)-1H-1,2,4-triazole

Guidance literature:

With allyl(cyclopentadiene)palladium(II); C₄₆H₃₄NO₃P; In toluene; at 50 ℃; for 3h; Overall yield = 69 %; Overall yield = 28.6 mg; enantioselective reaction; Inert atmosphere;

DOI:10.1002/anie.201300616

upstream raw materials:

[2-(acetoxymethyl)prop-2-enyl]trimethylsilane

1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone

(2R-cis)-2-(2,4-difluorophenyl)-4-[[(4-methylphenyl)sulfonyloxy]methyl]-2-[(1H-1,2,4-triazol-1-yl)methyl]tetrahydrofuran

tert-butyl 4-(4-hydroxyphenyl)piperazine-1-carboxylate