2,5-dihydro-2-oxo-3-phenyl-4-(trifluoromethylsulfonoxy)-1H-pyrrole

Base Information

• Chemical Name: 2,5-dihydro-2-oxo-3-phenyl-4-(trifluoromethylsulfonoxy)-1H-pyrrole
• CAS No.: 1174430-25-1
• Molecular Formula: C₁₁H₈F₃NO₄S
• Molecular Weight: 307.25
• Mol file: 1174430-25-1.mol

Synonyms:2,5-dihydro-2-oxo-3-phenyl-4-(trifluoromethylsulfonoxy)-1H-pyrrole

Chemical Property of 2,5-dihydro-2-oxo-3-phenyl-4-(trifluoromethylsulfonoxy)-1H-pyrrole

Chemical Property:

Purity/Quality:

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Technology Process of 2,5-dihydro-2-oxo-3-phenyl-4-(trifluoromethylsulfonoxy)-1H-pyrrole

There total 1 articles about 2,5-dihydro-2-oxo-3-phenyl-4-(trifluoromethylsulfonoxy)-1H-pyrrole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

tert-butyl 2,5-dihydro-2-oxo-3-phenyl-4-(trifluoromethylsulfonoxy)-1H-pyrrole-1-carboxylate (1174430-21-7) → 2,5-dihydro-2-oxo-3-phenyl-4-(trifluoromethylsulfonoxy)-1H-pyrrole (1174430-25-1)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; Inert atmosphere;

DOI:10.1002/jhet.96

Reference yield: 64.0%

2,5-dihydro-2-oxo-3-phenyl-4-(trifluoromethylsulfonoxy)-1H-pyrrole (1174430-25-1) + 3,4,5-trimethoxyphenylboronic Acid (182163-96-8) → 3-phenyl-4-(3’,4’,5’-trimethoxyphenyl)-1H-pyrrol-2(5H)-one

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In tetrahydrofuran; water; at 20 ℃; Inert atmosphere; Reflux;

DOI:10.1016/j.bmcl.2016.11.076

Reference yield: 62.0%

2,5-dihydro-2-oxo-3-phenyl-4-(trifluoromethylsulfonoxy)-1H-pyrrole (1174430-25-1) + 4-methoxyphenylboronic acid (5720-07-0) → 2,5-dihydro-4-(4'-methoxyphenyl)-2-oxo-3-phenyl-1H-pyrrole

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In tetrahydrofuran; water; at 20 ℃; Reflux; Inert atmosphere;

DOI:10.1002/jhet.96

upstream raw materials:

tert-butyl 2,5-dihydro-2-oxo-3-phenyl-4-(trifluoromethylsulfonoxy)-1H-pyrrole-1-carboxylate