1-(5-(3-amino-4-hydroxy-5-methoxyphenyl)-3-(2-bromophenyl)-4,5-dihydropyrazol-1-yl)ethanone

Base Information

• Chemical Name: 1-(5-(3-amino-4-hydroxy-5-methoxyphenyl)-3-(2-bromophenyl)-4,5-dihydropyrazol-1-yl)ethanone
• CAS No.: 1472645-98-9
• Molecular Formula: C₁₈H₁₈BrN₃O₃
• Molecular Weight: 404.263
• Mol file: 1472645-98-9.mol

Synonyms:1-(5-(3-amino-4-hydroxy-5-methoxyphenyl)-3-(2-bromophenyl)-4,5-dihydropyrazol-1-yl)ethanone

Chemical Property of 1-(5-(3-amino-4-hydroxy-5-methoxyphenyl)-3-(2-bromophenyl)-4,5-dihydropyrazol-1-yl)ethanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(5-(3-amino-4-hydroxy-5-methoxyphenyl)-3-(2-bromophenyl)-4,5-dihydropyrazol-1-yl)ethanone

There total 4 articles about 1-(5-(3-amino-4-hydroxy-5-methoxyphenyl)-3-(2-bromophenyl)-4,5-dihydropyrazol-1-yl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.5%

C18H16BrN3O5 (1472646-44-8) → 1-(5-(3-amino-4-hydroxy-5-methoxyphenyl)-3-(2-bromophenyl)-4,5-dihydropyrazol-1-yl)ethanone (1472645-98-9)

Guidance literature:

With sodium dithionite; In methanol; at 55 - 60 ℃; for 0.5h;

DOI:10.1007/s00044-013-0815-x

Reference yield:

isonitrovanillin (6635-20-7) → 1-(5-(3-amino-4-hydroxy-5-methoxyphenyl)-3-(2-bromophenyl)-4,5-dihydropyrazol-1-yl)ethanone (1472645-98-9)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydroxide / methanol; water / 20 h / 20 - 25 °C

2: hydrazine hydrate / 3 h / Reflux

3: sodium dithionite / methanol / 0.5 h / 55 - 60 °C

With sodium dithionite; hydrazine hydrate; sodium hydroxide; In methanol; water; 1: |Aldol Condensation;

DOI:10.1007/s00044-013-0815-x

Reference yield:

2-bromophenyl methyl ketone (2142-69-0) → 1-(5-(3-amino-4-hydroxy-5-methoxyphenyl)-3-(2-bromophenyl)-4,5-dihydropyrazol-1-yl)ethanone (1472645-98-9)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydroxide / methanol; water / 20 h / 20 - 25 °C

2: hydrazine hydrate / 3 h / Reflux

3: sodium dithionite / methanol / 0.5 h / 55 - 60 °C

With sodium dithionite; hydrazine hydrate; sodium hydroxide; In methanol; water; 1: |Aldol Condensation;

DOI:10.1007/s00044-013-0815-x

upstream raw materials:

C₁₈H₁₆BrN₃O₅

isonitrovanillin

2-bromophenyl methyl ketone

C₁₆H₁₂BrNO₅

Downstream raw materials:

1-(5-(2-amino-7-methoxybenzoxazol-5-yl)-3-(2-bromophenyl)-4,5-dihydro-1H-pyrazol-1-yl)ethanone

1-(5-(2-mercapto-7-methoxybenzoxazol-5-yl)-3-(2-bromophenyl)-4,5-dihydro-1H-pyrazol-1-yl)ethanone