3,6-dimethyl-octa-2,6-dienedioic acid diethyl ester

Base Information

• Chemical Name: 3,6-dimethyl-octa-2,6-dienedioic acid diethyl ester
• CAS No.: 15898-66-5
• Molecular Formula: C₁₄H₂₂O₄
• Molecular Weight: 254.326
• Mol file: 15898-66-5.mol

Synonyms:3,6-dimethyl-octa-2,6-dienedioic acid diethyl ester

Chemical Property of 3,6-dimethyl-octa-2,6-dienedioic acid diethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3,6-dimethyl-octa-2,6-dienedioic acid diethyl ester

There total 1 articles about 3,6-dimethyl-octa-2,6-dienedioic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 4-bromo-3-methylcrotonate (51318-62-8,51371-55-2,26918-14-9) → 3,6-dimethyl-octa-2,6-dienedioic acid diethyl ester (15898-66-5)

Guidance literature:

tetracarbonyl nickel; In benzene; at 50 ℃; for 2h;

DOI:10.1021/jo00968a029

Reference yield:

3,6-dimethyl-octa-2,6-dienedioic acid diethyl ester (15898-66-5) → (2E,6E)-8-(3-chloro-5-formyl-2,6-dihydroxy-4-methylphenyl)-3,6-dimethyl-2,6-octadienyl pivalate (1374767-37-9)

Guidance literature:

Multi-step reaction with 4 steps

1.1: diisobutylaluminium hydride / hexane; toluene / 3 h / -70 °C

1.2: 0.17 h / -70 - 20 °C

2.1: triethylamine; dmap / chloroform / 12 h / 0 - 20 °C

3.1: carbon tetrabromide; cyanex-921 / diethyl ether / 2 h / 0 °C

4.1: potassium hydroxide; calcium(II) chloride dihydrate / methanol / 14 h / 0 - 20 °C

With dmap; calcium(II) chloride dihydrate; carbon tetrabromide; cyanex-921; diisobutylaluminium hydride; triethylamine; potassium hydroxide; In methanol; diethyl ether; hexane; chloroform; toluene;

upstream raw materials:

ethyl 4-bromo-3-methylcrotonate

Downstream raw materials:

(2E,6E)-8-(3-chloro-5-formyl-2,6-dihydroxy-4-methylphenyl)-3,6-dimethyl-2,6-octadienyl pivalate