N-[(Z)-(dimethylamino)methylidene]-4-[6-(4-fluorophenyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-3-yl]benzenesulfonamide

Base Information

• Chemical Name: N-[(Z)-(dimethylamino)methylidene]-4-[6-(4-fluorophenyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-3-yl]benzenesulfonamide
• CAS No.: 1580457-23-3
• Molecular Formula: C₁₈H₁₅FN₆O₂S₂
• Molecular Weight: 430.487

Synonyms:N-[(Z)-(dimethylamino)methylidene]-4-[6-(4-fluorophenyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-3-yl]benzenesulfonamide

Chemical Property of N-[(Z)-(dimethylamino)methylidene]-4-[6-(4-fluorophenyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-3-yl]benzenesulfonamide

Chemical Property:

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Technology Process of N-[(Z)-(dimethylamino)methylidene]-4-[6-(4-fluorophenyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-3-yl]benzenesulfonamide

There total 7 articles about N-[(Z)-(dimethylamino)methylidene]-4-[6-(4-fluorophenyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-3-yl]benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

4-Fluorobenzoic acid (456-22-4) + 4-(4-amino-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)-N-[(Z)-(dimethylamino)methylidene]benzenesulfonamide (1580456-73-0) → N-[(Z)-(dimethylamino)methylidene]-4-[6-(4-fluorophenyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-3-yl]benzenesulfonamide (1580457-23-3)

Guidance literature:

With trichlorophosphate; Reflux;

DOI:10.1016/j.bmc.2014.01.055

Reference yield:

toluene-4-sulfonamide (70-55-3) → N-[(Z)-(dimethylamino)methylidene]-4-[6-(4-fluorophenyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-3-yl]benzenesulfonamide (1580457-23-3)

Guidance literature:

Multi-step reaction with 7 steps

1: potassium permanganate / water / Reflux

2: Reflux; Acidic conditions

3: hydrazine hydrate / methanol / Reflux

4: potassium hydroxide / ethanol

5: hydrazine hydrate / water / 20 h / Reflux

6: 40 °C

7: trichlorophosphate / Reflux

With potassium permanganate; hydrazine hydrate; potassium hydroxide; trichlorophosphate; In methanol; ethanol; water;

DOI:10.1016/j.bmc.2014.01.055

Reference yield:

4-(aminosulfonyl)-benzoic acid (138-41-0) → N-[(Z)-(dimethylamino)methylidene]-4-[6-(4-fluorophenyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-3-yl]benzenesulfonamide (1580457-23-3)

Guidance literature:

Multi-step reaction with 6 steps

1: Reflux; Acidic conditions

2: hydrazine hydrate / methanol / Reflux

3: potassium hydroxide / ethanol

4: hydrazine hydrate / water / 20 h / Reflux

5: 40 °C

6: trichlorophosphate / Reflux

With hydrazine hydrate; potassium hydroxide; trichlorophosphate; In methanol; ethanol; water;

DOI:10.1016/j.bmc.2014.01.055

upstream raw materials:

toluene-4-sulfonamide

4-(aminosulfonyl)-benzoic acid

methyl 4-sulfamoylbenzoate

4-(hydrazinecarbonyl)benzene-1-sulfonamide

Downstream raw materials:

4-[6-(4-fluorophenyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-3-yl]benzenesulfonamide

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