2-[(6S,9R)-9-amino-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5H-imidazo[1,2-a]azepin-3-yl]propan-2-ol

Base Information

Chemical Name:2-[(6S,9R)-9-amino-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5H-imidazo[1,2-a]azepin-3-yl]propan-2-ol
CAS No.:880144-50-3
Molecular Formula:C₁₇H₂₁F₂N₃O
Molecular Weight:321.37
Hs Code.:

Synonyms:2-[(6S,9R)-9-amino-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5H-imidazo[1,2-a]azepin-3-yl]propan-2-ol

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Chemical Property of 2-[(6S,9R)-9-amino-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5H-imidazo[1,2-a]azepin-3-yl]propan-2-ol

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Technology Process of 2-[(6S,9R)-9-amino-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5H-imidazo[1,2-a]azepin-3-yl]propan-2-ol

There total 10 articles about 2-[(6S,9R)-9-amino-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5H-imidazo[1,2-a]azepin-3-yl]propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 880144-49-0
tert-butyl [(6S,9R)-6-(2,3-difluorophenyl)-3-(1-methoxy-1-methylethyl)-6,7,8,9-tetrahydro-5H-imidazo[1,2-a]azepin-9-yl]carbamate

: 880144-50-3
2-[(6S,9R)-9-amino-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5H-imidazo[1,2-a]azepin-3-yl]propan-2-ol

Guidance literature:: tert-butyl [(6S,9R)-6-(2,3-difluorophenyl)-3-(1-methoxy-1-methylethyl)-6,7,8,9-tetrahydro-5H-imidazo[1,2-a]azepin-9-yl]carbamate; With sulfuric acid; In water; at 60 ℃; for 2.5h;

With sodium hydrogencarbonate; In water;

Reference yield:

: 781650-32-6
tert-butyl [(3R,6S)-6-(2,3-difluorophenyl)-2-oxoazepan-3-yl]carbamate

: 880144-50-3
2-[(6S,9R)-9-amino-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5H-imidazo[1,2-a]azepin-3-yl]propan-2-ol

Guidance literature:: Multi-step reaction with 4 steps

1: Lawessons reagent / 90 °C

2: mercury dichloride / ethanol / 55 °C

3: dipyridinium dichromate / acetonitrile

4: trifluoroacetic acid / dichloromethane

With Lawessons reagent; dipyridinium dichromate; trifluoroacetic acid; mercury dichloride; In ethanol; dichloromethane; acetonitrile;
DOI:10.1016/j.bmcl.2010.12.054

Reference yield:

: 880144-46-7
tert-butyl (3R,6S)-6-(2,3-difluorophenyl)-2-thioxoazepan-3-ylcarbamate

: 880144-50-3
2-[(6S,9R)-9-amino-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5H-imidazo[1,2-a]azepin-3-yl]propan-2-ol

Guidance literature:: Multi-step reaction with 3 steps

1: mercury dichloride / ethanol / 55 °C

2: dipyridinium dichromate / acetonitrile

3: trifluoroacetic acid / dichloromethane

With dipyridinium dichromate; trifluoroacetic acid; mercury dichloride; In ethanol; dichloromethane; acetonitrile;
DOI:10.1016/j.bmcl.2010.12.054