Carbamic acid, [(6S,9R)-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-3-(1-methoxy-1-meth ylethyl)-5H-imidazo[1,2-a]azepin-9-yl]-, 1,1-dimethylethyl ester

Base Information

Chemical Name:Carbamic acid, [(6S,9R)-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-3-(1-methoxy-1-meth ylethyl)-5H-imidazo[1,2-a]azepin-9-yl]-, 1,1-dimethylethyl ester
CAS No.:880144-49-0
Molecular Formula:C23H31F2N3O3
Molecular Weight:435.514
Hs Code.:

Carbamic acid,
[(6S,9R)-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-3-(1-methoxy-1-meth
ylethyl)-5H-imidazo[1,2-a]azepin-9-yl]-, 1,1-dimethylethyl ester

Synonyms:

Suppliers and Price of Carbamic acid, [(6S,9R)-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-3-(1-methoxy-1-meth ylethyl)-5H-imidazo[1,2-a]azepin-9-yl]-, 1,1-dimethylethyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Carbamic acid, [(6S,9R)-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-3-(1-methoxy-1-meth ylethyl)-5H-imidazo[1,2-a]azepin-9-yl]-, 1,1-dimethylethyl ester

Chemical Property:

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Technology Process of Carbamic acid, [(6S,9R)-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-3-(1-methoxy-1-meth ylethyl)-5H-imidazo[1,2-a]azepin-9-yl]-, 1,1-dimethylethyl ester

There total 5 articles about Carbamic acid, [(6S,9R)-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-3-(1-methoxy-1-meth ylethyl)-5H-imidazo[1,2-a]azepin-9-yl]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 781650-32-6
tert-butyl [(3R,6S)-6-(2,3-difluorophenyl)-2-oxoazepan-3-yl]carbamate

: 880144-49-0
tert-butyl [(6S,9R)-6-(2,3-difluorophenyl)-3-(1-methoxy-1-methylethyl)-6,7,8,9-tetrahydro-5H-imidazo[1,2-a]azepin-9-yl]carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: Lawessons reagent / 90 °C

2: mercury dichloride / ethanol / 55 °C

3: dipyridinium dichromate / acetonitrile

With Lawessons reagent; dipyridinium dichromate; mercury dichloride; In ethanol; acetonitrile;
DOI:10.1016/j.bmcl.2010.12.054

Reference yield:

: 885032-36-0
1-amino-3-methoxy-3-methylbutan-2-ol

: 880144-49-0
tert-butyl [(6S,9R)-6-(2,3-difluorophenyl)-3-(1-methoxy-1-methylethyl)-6,7,8,9-tetrahydro-5H-imidazo[1,2-a]azepin-9-yl]carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: mercury dichloride / ethanol / 55 °C

2: dipyridinium dichromate / acetonitrile

With dipyridinium dichromate; mercury dichloride; In ethanol; acetonitrile;
DOI:10.1016/j.bmcl.2010.12.054

Reference yield:

: 880144-46-7
tert-butyl (3R,6S)-6-(2,3-difluorophenyl)-2-thioxoazepan-3-ylcarbamate

: 880144-49-0
tert-butyl [(6S,9R)-6-(2,3-difluorophenyl)-3-(1-methoxy-1-methylethyl)-6,7,8,9-tetrahydro-5H-imidazo[1,2-a]azepin-9-yl]carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: mercury dichloride / ethanol / 55 °C

2: dipyridinium dichromate / acetonitrile

With dipyridinium dichromate; mercury dichloride; In ethanol; acetonitrile;
DOI:10.1016/j.bmcl.2010.12.054