1-(2-fluoro-4-{2-[3-methyl-3-(1-methylpiperidin-4-yl)ureido]pyridin-4-yloxy}phenyl)carbamoylcyclopropanecarboxylic acid

Base Information

Chemical Name:1-(2-fluoro-4-{2-[3-methyl-3-(1-methylpiperidin-4-yl)ureido]pyridin-4-yloxy}phenyl)carbamoylcyclopropanecarboxylic acid
CAS No.:928038-24-8
Molecular Formula:C₂₄H₂₈FN₅O₅
Molecular Weight:485.515
Hs Code.:

Synonyms:1-(2-fluoro-4-{2-[3-methyl-3-(1-methylpiperidin-4-yl)ureido]pyridin-4-yloxy}phenyl)carbamoylcyclopropanecarboxylic acid

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Chemical Property of 1-(2-fluoro-4-{2-[3-methyl-3-(1-methylpiperidin-4-yl)ureido]pyridin-4-yloxy}phenyl)carbamoylcyclopropanecarboxylic acid

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Technology Process of 1-(2-fluoro-4-{2-[3-methyl-3-(1-methylpiperidin-4-yl)ureido]pyridin-4-yloxy}phenyl)carbamoylcyclopropanecarboxylic acid

There total 8 articles about 1-(2-fluoro-4-{2-[3-methyl-3-(1-methylpiperidin-4-yl)ureido]pyridin-4-yloxy}phenyl)carbamoylcyclopropanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 928038-23-7
1-(benzyloxycarbonyl)-N-(2-fluoro-4-{2-[3-methyl-3-(1-methylpiperidin-4-yl)ureido]pyridin-4-yloxy}phenyl)cyclopropanecarboxamide

: 928038-24-8
1-(2-fluoro-4-{2-[3-methyl-3-(1-methylpiperidin-4-yl)ureido]pyridin-4-yloxy}phenyl)carbamoylcyclopropanecarboxylic acid

Guidance literature:: With hydrogen; palladium(II) hydroxide/carbon; In tetrahydrofuran; methanol; at 20 ℃; for 24h;

Reference yield:

: 870647-41-9
1-(benzyloxycarbonyl)cyclopropanecarboxylic acid

: 928038-24-8
1-(2-fluoro-4-{2-[3-methyl-3-(1-methylpiperidin-4-yl)ureido]pyridin-4-yloxy}phenyl)carbamoylcyclopropanecarboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 20 °C

2: N,N-dimethyl-formamide / 4 h / 20 °C

3: hydrogen / palladium(II) hydroxide/carbon / tetrahydrofuran; methanol / 24 h / 20 °C

With hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; palladium(II) hydroxide/carbon; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

Reference yield:

: 864245-68-1
benzyl (4-((2-aminopyridin-4-yl)oxy)-2-fluorophenyl)carbamate

: 928038-24-8
1-(2-fluoro-4-{2-[3-methyl-3-(1-methylpiperidin-4-yl)ureido]pyridin-4-yloxy}phenyl)carbamoylcyclopropanecarboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine / tetrahydrofuran / 1 h / 20 °C

2: hydrogen / palladium(II) hydroxide/carbon / tetrahydrofuran / 4 h / 20 °C

3: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 20 °C

4: N,N-dimethyl-formamide / 4 h / 20 °C

5: hydrogen / palladium(II) hydroxide/carbon / tetrahydrofuran; methanol / 24 h / 20 °C

With hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; palladium(II) hydroxide/carbon; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;