1-(benzyloxycarbonyl)-N-(2-fluoro-4-{2-[3-methyl-3-(1-methylpiperidin-4-yl)ureido]pyridin-4-yloxy}phenyl)cyclopropanecarboxamide

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Chemical Name:1-(benzyloxycarbonyl)-N-(2-fluoro-4-{2-[3-methyl-3-(1-methylpiperidin-4-yl)ureido]pyridin-4-yloxy}phenyl)cyclopropanecarboxamide
CAS No.:928038-23-7
Molecular Formula:C₃₁H₃₄FN₅O₅
Molecular Weight:575.64
Hs Code.:

Synonyms:1-(benzyloxycarbonyl)-N-(2-fluoro-4-{2-[3-methyl-3-(1-methylpiperidin-4-yl)ureido]pyridin-4-yloxy}phenyl)cyclopropanecarboxamide

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Chemical Property of 1-(benzyloxycarbonyl)-N-(2-fluoro-4-{2-[3-methyl-3-(1-methylpiperidin-4-yl)ureido]pyridin-4-yloxy}phenyl)cyclopropanecarboxamide

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Technology Process of 1-(benzyloxycarbonyl)-N-(2-fluoro-4-{2-[3-methyl-3-(1-methylpiperidin-4-yl)ureido]pyridin-4-yloxy}phenyl)cyclopropanecarboxamide

There total 8 articles about 1-(benzyloxycarbonyl)-N-(2-fluoro-4-{2-[3-methyl-3-(1-methylpiperidin-4-yl)ureido]pyridin-4-yloxy}phenyl)cyclopropanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 73579-08-5
Methyl-(1-methyl-[4]piperidyl)-amin

: 928038-22-6
[4-(4-{[1-(benzyloxycarbonyl)cyclopropanecarbonyl]amino}-3-fluoro-phenoxy)-pyridin-2-yl]-N-(phenoxycarbonyl)carbamic acid phenyl ester

: 928038-23-7
1-(benzyloxycarbonyl)-N-(2-fluoro-4-{2-[3-methyl-3-(1-methylpiperidin-4-yl)ureido]pyridin-4-yloxy}phenyl)cyclopropanecarboxamide

Guidance literature:: In N,N-dimethyl-formamide; at 20 ℃; for 4h;

Reference yield:

: 864245-68-1
benzyl (4-((2-aminopyridin-4-yl)oxy)-2-fluorophenyl)carbamate

: 928038-23-7
1-(benzyloxycarbonyl)-N-(2-fluoro-4-{2-[3-methyl-3-(1-methylpiperidin-4-yl)ureido]pyridin-4-yloxy}phenyl)cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / tetrahydrofuran / 1 h / 20 °C

2: hydrogen / palladium(II) hydroxide/carbon / tetrahydrofuran / 4 h / 20 °C

3: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 20 °C

4: N,N-dimethyl-formamide / 4 h / 20 °C

With hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; palladium(II) hydroxide/carbon; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 864245-67-0
4-(4-benzyloxycarbonylamino-3-fluorophenoxy)pyridine-2-carboxylic acid

: 928038-23-7
1-(benzyloxycarbonyl)-N-(2-fluoro-4-{2-[3-methyl-3-(1-methylpiperidin-4-yl)ureido]pyridin-4-yloxy}phenyl)cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 6 steps

1: diphenyl phosphoryl azide; triethylamine / 5 h / 20 - 100 °C

2: hydrogenchloride / ethyl acetate / 3.67 h / 0 - 20 °C

3: triethylamine / tetrahydrofuran / 1 h / 20 °C

4: hydrogen / palladium(II) hydroxide/carbon / tetrahydrofuran / 4 h / 20 °C

5: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 20 °C

6: N,N-dimethyl-formamide / 4 h / 20 °C

With hydrogenchloride; diphenyl phosphoryl azide; hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; palladium(II) hydroxide/carbon; In tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide;