2-azidomethyl-3-cyanopyridine

Base Information

• Chemical Name: 2-azidomethyl-3-cyanopyridine
• CAS No.: 817555-73-0
• Molecular Formula: C₁₃H₉N₅
• Molecular Weight: 235.248
• Mol file: 817555-73-0.mol

Synonyms:2-azidomethyl-3-cyanopyridine

Chemical Property of 2-azidomethyl-3-cyanopyridine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-azidomethyl-3-cyanopyridine

There total 4 articles about 2-azidomethyl-3-cyanopyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

2-chloromethyl-4-phenyl-nicotinonitrile (817555-70-7) → 2-azidomethyl-3-cyanopyridine (817555-73-0)

Guidance literature:

With sodium azide; In dimethyl sulfoxide; at 20 ℃; for 1h;

DOI:10.1016/j.tetlet.2004.10.016

Reference yield:

3-cyano-2-methyl-4-phenylpyridine (102147-20-6) → 2-azidomethyl-3-cyanopyridine (817555-73-0)

Guidance literature:

Multi-step reaction with 5 steps

1: 63 percent / aq. H₂O₂ / acetic acid / 70 °C

2: CH₂Cl₂ / 3 h / 20 - 50 °C

3: 1.45 g / MeOH / 20 °C

4: 100 percent / methanesulfonyl chloride; triethylamine / CH₂Cl₂ / 13 h / 0 - 20 °C

5: 96 percent / NaN₃ / dimethylsulfoxide / 1 h / 20 °C

With methanol; sodium azide; dihydrogen peroxide; methanesulfonyl chloride; triethylamine; In dichloromethane; acetic acid; dimethyl sulfoxide;

DOI:10.1016/j.tetlet.2004.10.016

Reference yield:

2-hydroxymethyl-4-phenyl-nicotinonitrile (817555-66-1) → 2-azidomethyl-3-cyanopyridine (817555-73-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / methanesulfonyl chloride; triethylamine / CH₂Cl₂ / 13 h / 0 - 20 °C

2: 96 percent / NaN₃ / dimethylsulfoxide / 1 h / 20 °C

With sodium azide; methanesulfonyl chloride; triethylamine; In dichloromethane; dimethyl sulfoxide;

DOI:10.1016/j.tetlet.2004.10.016

upstream raw materials:

2-chloromethyl-4-phenyl-nicotinonitrile

3-cyano-2-methyl-4-phenylpyridine

2-hydroxymethyl-4-phenyl-nicotinonitrile