102147-20-6

Basic information

• Product Name: 2-methyl-4-phenylnicotinonitrile(SALTDATA: FREE)
• Synonyms: 2-methyl-4-phenylnicotinonitrile(SALTDATA: FREE);2-methyl-4-phenylnicotinonitrile
• CAS NO: 102147-20-6
• Molecular Formula: C₁₃H₁₀N₂
• Molecular Weight: 194.2319
• Mol File: 102147-20-6.mol

Chemical Properties

• Melting Point: 135 °C
• Boiling Point: 340.9±30.0 °C(Predicted)
• Appearance: /
• Density: 1.14±0.1 g/cm3(Predicted)
• PKA: 2.66±0.18(Predicted)
• CAS DataBase Reference: 2-methyl-4-phenylnicotinonitrile(SALTDATA: FREE)(CAS DataBase Reference)
• NIST Chemistry Reference: 2-methyl-4-phenylnicotinonitrile(SALTDATA: FREE)(102147-20-6)
• EPA Substance Registry System: 2-methyl-4-phenylnicotinonitrile(SALTDATA: FREE)(102147-20-6)

Safety Data

• Hazardous Substances Data: 102147-20-6(Hazardous Substances Data)

Upstream product

• 98-86-2 acetophenone 
• 242474-65-3 3-amino-2-(1-phenylvinyl)-2-butenenitrile 
• 1201-93-0 1-phenyl-3-dimethylaminoprop-2-enone 
• 1118-61-2 3-Aminocrotononitrile 
• 187964-68-7 N-(1H-1,2,3-benzotriazol-1-ylmethylene)-N-methylmethanaminium chloride 
• 14371-10-9 (E)-3-phenylpropenal 
• 1118-60-1 3-iminobutyronitrile 

Downstream Products

• 817555-73-0 2-azidomethyl-3-cyanopyridine 
• 817555-70-7 2-chloromethyl-4-phenyl-nicotinonitrile 
• 817555-66-1 2-hydroxymethyl-4-phenyl-nicotinonitrile 
• 817555-63-8 2-methyl-1-oxy-4-phenyl-nicotinonitrile 
• 682807-09-6 2-methyl-4-phenyl-3-(2H-tetrazol-5-yl)-pyridine 

Relevant articles and documents

β-Carbolines: synthesis of harmane, harmine alkaloids and their structural analogs by thermolysis of 4-aryl-3-azidopyridines and investigation of their optical properties

[Figure not available: see fulltext.] Interest in β-carbolines is caused by the biological activity of these compounds and the use of their fluorescent properties in the study of their interaction with DNA and other biological targets, as well as with drug delivery vehicles. A new general method for the synthesis of harmane, harmine, and their structural analogs by thermolysis of substituted 4-aryl-3-azidopyridines was developed, and their optical properties were studied.

The Vinylogous Mannich Reaction: An Efficient Access to Substituted Nicotinonitriles

A straightforward method for the preparation of substituted nicotinonitriles has been developed. Starting from conjugated β-enaminonitriles and iminium salts, this methodology establishes a convenient access to 6-aryl- (5), 6-amino- (16) and 6-carboxylic ester-substituted derivatives 14 and as well to acetic acid-substituted pyrroles 12.

Enaminones as building blocks in organic synthesis: A novel route to polyfunctionally substituted benzonitriles, pyridines, eneylbenzotriazoles and diazepines

An efficient synthesis of enaminones 1a-c is reported. Compounds 1a-c reacted with diethyl-3-amino-2-cyanopenten-1,5-dicarboxylate (3) to yield the benzonitriles 6. On the other hand, the reaction of 1a-c with 3-amino-2-cyano-2-pentene dinitrile (7) affor

A simple and versatile route to novel conjugated β-enaminonitriles and their application for the highly regioselective synthesis of nicotinonitriles using a Vilsmeier-type reagent

A straightforward synthesis of conjugated β-enaminonitriles from ketones and β-aminocrotononitrile mediated by TiCl4 is described. The reaction of these novel dienamines with a Vilsmeier-type reagent provides a mild and highly regioselective route for the preparation of nicotinonitriles.

A Convenient Synthesis of 3-Cyano-2-methylpyridines under Ultrasonic Irradiation

Ultrasonic irradiation of α,β-unsaturated carbonyl compounds 1a-i with acetonitrile in the presence of pottasium t-butoxide gave 3-cyano-2-methylpyridines 2a-i in moderate to good yields.The pyridines are produced by a Michael reaction of 3-iminobutanonitrile, an acetonitrile dimer, to the substrates 1a-i.