3-[2-(4-chlorophenyl)-3-(methyloxy)-3-oxopropanoyl]-2-pyrazinecarboxylic acid

Base Information

• Chemical Name: 3-[2-(4-chlorophenyl)-3-(methyloxy)-3-oxopropanoyl]-2-pyrazinecarboxylic acid
• CAS No.: 1401246-69-2
• Molecular Formula: C₁₅H₁₁ClN₂O₅
• Molecular Weight: 334.716
• Mol file: 1401246-69-2.mol

Synonyms:3-[2-(4-chlorophenyl)-3-(methyloxy)-3-oxopropanoyl]-2-pyrazinecarboxylic acid

Chemical Property of 3-[2-(4-chlorophenyl)-3-(methyloxy)-3-oxopropanoyl]-2-pyrazinecarboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-[2-(4-chlorophenyl)-3-(methyloxy)-3-oxopropanoyl]-2-pyrazinecarboxylic acid

There total 2 articles about 3-[2-(4-chlorophenyl)-3-(methyloxy)-3-oxopropanoyl]-2-pyrazinecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-[(methyloxy)carbonyl]-2-pyrazinecarboxylic acid (73763-86-7) + (4-chloro-phenyl)-acetic acid methyl ester (52449-43-1) → methyl 3-[2-(4-chlorophenyl)-3-(methyloxy)-3-oxopropanoyl]-2-pyrazinecarboxylate (1401246-68-1) + 3-[2-(4-chlorophenyl)-3-(methyloxy)-3-oxopropanoyl]-2-pyrazinecarboxylic acid (1401246-69-2)

Guidance literature:

3-[(methyloxy)carbonyl]-2-pyrazinecarboxylic acid; With 1,1'-carbonyldiimidazole; In N,N-dimethyl-formamide; at 61 ℃; for 4.5h; Inert atmosphere;

(4-chloro-phenyl)-acetic acid methyl ester; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 5 ℃; for 1.5h; Overall yield = 99 %; Overall yield = 3.62 g; Inert atmosphere;

DOI:10.1016/j.bmc.2012.08.032

Reference yield:

2,3-pyrazinedicarboxylic anhydride (4744-50-7) → methyl 3-[2-(4-chlorophenyl)-3-(methyloxy)-3-oxopropanoyl]-2-pyrazinecarboxylate (1401246-68-1) + 3-[2-(4-chlorophenyl)-3-(methyloxy)-3-oxopropanoyl]-2-pyrazinecarboxylic acid (1401246-69-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 72 h / 20 °C

2.1: 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide / 4.5 h / 61 °C / Inert atmosphere

2.2: 1.5 h / 5 °C / Inert atmosphere

With 1,1'-carbonyldiimidazole; In N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2012.08.032

upstream raw materials:

2,3-pyrazinedicarboxylic anhydride

3-[(methyloxy)carbonyl]-2-pyrazinecarboxylic acid

(4-chloro-phenyl)-acetic acid methyl ester