methyl 3-[2-(4-chlorophenyl)-3-(methyloxy)-3-oxopropanoyl]-2-pyrazinecarboxylate

Base Information

Chemical Name:methyl 3-[2-(4-chlorophenyl)-3-(methyloxy)-3-oxopropanoyl]-2-pyrazinecarboxylate
CAS No.:1401246-68-1
Molecular Formula:C₁₆H₁₃ClN₂O₅
Molecular Weight:348.743
Hs Code.:

Synonyms:methyl 3-[2-(4-chlorophenyl)-3-(methyloxy)-3-oxopropanoyl]-2-pyrazinecarboxylate

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Chemical Property of methyl 3-[2-(4-chlorophenyl)-3-(methyloxy)-3-oxopropanoyl]-2-pyrazinecarboxylate

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Technology Process of methyl 3-[2-(4-chlorophenyl)-3-(methyloxy)-3-oxopropanoyl]-2-pyrazinecarboxylate

There total 2 articles about methyl 3-[2-(4-chlorophenyl)-3-(methyloxy)-3-oxopropanoyl]-2-pyrazinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 73763-86-7
3-[(methyloxy)carbonyl]-2-pyrazinecarboxylic acid

: 52449-43-1
(4-chloro-phenyl)-acetic acid methyl ester

: 1401246-68-1
methyl 3-[2-(4-chlorophenyl)-3-(methyloxy)-3-oxopropanoyl]-2-pyrazinecarboxylate

: 1401246-69-2
3-[2-(4-chlorophenyl)-3-(methyloxy)-3-oxopropanoyl]-2-pyrazinecarboxylic acid

Guidance literature:: 3-[(methyloxy)carbonyl]-2-pyrazinecarboxylic acid; With 1,1'-carbonyldiimidazole; In N,N-dimethyl-formamide; at 61 ℃; for 4.5h; Inert atmosphere;

(4-chloro-phenyl)-acetic acid methyl ester; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 5 ℃; for 1.5h; Overall yield = 99 %; Overall yield = 3.62 g; Inert atmosphere;
DOI:10.1016/j.bmc.2012.08.032

Reference yield:

: 4744-50-7
2,3-pyrazinedicarboxylic anhydride

: 1401246-68-1
methyl 3-[2-(4-chlorophenyl)-3-(methyloxy)-3-oxopropanoyl]-2-pyrazinecarboxylate

: 1401246-69-2
3-[2-(4-chlorophenyl)-3-(methyloxy)-3-oxopropanoyl]-2-pyrazinecarboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: 72 h / 20 °C

2.1: 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide / 4.5 h / 61 °C / Inert atmosphere

2.2: 1.5 h / 5 °C / Inert atmosphere

With 1,1'-carbonyldiimidazole; In N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2012.08.032