2-[5-benzyloxycarbonylamino-2-(4-fluorophenyl)-6-oxo-1,6-dihydro-1-pyrimidinyl]-N-[1-[(5-carboxylbenzoxazol-2-yl)hydroxymethyl]-2-phenylethyl]acetamide

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Chemical Name:2-[5-benzyloxycarbonylamino-2-(4-fluorophenyl)-6-oxo-1,6-dihydro-1-pyrimidinyl]-N-[1-[(5-carboxylbenzoxazol-2-yl)hydroxymethyl]-2-phenylethyl]acetamide
CAS No.:207235-85-6
Molecular Formula:C₃₇H₃₀FN₅O₈
Molecular Weight:691.672
Hs Code.:

2-[5-benzyloxycarbonylamino-2-(4-fluorophenyl)-6-oxo-1,6-dihydro-1-pyrimidinyl]-N-[1-[(5-carboxylbenzoxazol-2-yl)hydroxymethyl]-2-phenylethyl]acetamide

Synonyms:2-[5-benzyloxycarbonylamino-2-(4-fluorophenyl)-6-oxo-1,6-dihydro-1-pyrimidinyl]-N-[1-[(5-carboxylbenzoxazol-2-yl)hydroxymethyl]-2-phenylethyl]acetamide

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Chemical Property of 2-[5-benzyloxycarbonylamino-2-(4-fluorophenyl)-6-oxo-1,6-dihydro-1-pyrimidinyl]-N-[1-[(5-carboxylbenzoxazol-2-yl)hydroxymethyl]-2-phenylethyl]acetamide

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Technology Process of 2-[5-benzyloxycarbonylamino-2-(4-fluorophenyl)-6-oxo-1,6-dihydro-1-pyrimidinyl]-N-[1-[(5-carboxylbenzoxazol-2-yl)hydroxymethyl]-2-phenylethyl]acetamide

There total 7 articles about 2-[5-benzyloxycarbonylamino-2-(4-fluorophenyl)-6-oxo-1,6-dihydro-1-pyrimidinyl]-N-[1-[(5-carboxylbenzoxazol-2-yl)hydroxymethyl]-2-phenylethyl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 207235-80-1
2-[5-benzyloxycarbonylamino-2-(4-fluorophenyl)-6-oxo-1,6-dihydro-1-pyrimidinyl]-N-[1-[[5-(methoxycarbonyl)benzoxazol-2-yl]hydroxymethyl]-2-phenylethyl]acetamide

: 207235-85-6
2-[5-benzyloxycarbonylamino-2-(4-fluorophenyl)-6-oxo-1,6-dihydro-1-pyrimidinyl]-N-[1-[(5-carboxylbenzoxazol-2-yl)hydroxymethyl]-2-phenylethyl]acetamide

Guidance literature:: With sodium hydroxide; In dimethyl sulfoxide; at 20 ℃; for 1h;
DOI:10.1021/jm000496v

Reference yield:

: 59830-60-3,63219-70-5,68474-26-0
N-benzyloxycarbonyl-2-amino-3-phenylpropionaldehyde

: 207235-85-6
2-[5-benzyloxycarbonylamino-2-(4-fluorophenyl)-6-oxo-1,6-dihydro-1-pyrimidinyl]-N-[1-[(5-carboxylbenzoxazol-2-yl)hydroxymethyl]-2-phenylethyl]acetamide

Guidance literature:: Multi-step reaction with 6 steps

1: 94 percent / Et₃N / CH₂Cl₂ / 4 h / 20 °C

2: HCl / CHCl₃ / 3 h / 0 °C

3: ethanol / 6 h / Heating

4: H₂ / 10percent Pd/C / methanol / 18 h / 20 °C

5: 3-hydroxybenzotriazole hydrate; 1-[3(dimethylamino)propyl]-3-ethylcarbodiimide hydrochloride / dimethylformamide / 4 h / 20 °C

6: 81 percent / 1 N aq. NaOH / dimethylsulfoxide / 1 h / 20 °C

With hydrogenchloride; sodium hydroxide; hydrogen; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; 10percent Pd/C; In methanol; ethanol; dichloromethane; chloroform; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jm000496v

Reference yield:

: 536-25-4
methyl 3-amino-4-hydroxybenzoate

: 207235-85-6
2-[5-benzyloxycarbonylamino-2-(4-fluorophenyl)-6-oxo-1,6-dihydro-1-pyrimidinyl]-N-[1-[(5-carboxylbenzoxazol-2-yl)hydroxymethyl]-2-phenylethyl]acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: ethanol / 6 h / Heating

2: H₂ / 10percent Pd/C / methanol / 18 h / 20 °C

3: 3-hydroxybenzotriazole hydrate; 1-[3(dimethylamino)propyl]-3-ethylcarbodiimide hydrochloride / dimethylformamide / 4 h / 20 °C

4: 81 percent / 1 N aq. NaOH / dimethylsulfoxide / 1 h / 20 °C

With sodium hydroxide; hydrogen; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 10percent Pd/C; In methanol; ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jm000496v