2-[5-benzyloxycarbonylamino-2-(4-fluorophenyl)-6-oxo-1,6-dihydro-1-pyrimidinyl]-N-[1-[(5-carbamoylbenzoxazol-2-yl)hydroxymethyl]-2-phenylethyl]acetamide

Base Information

Chemical Name:2-[5-benzyloxycarbonylamino-2-(4-fluorophenyl)-6-oxo-1,6-dihydro-1-pyrimidinyl]-N-[1-[(5-carbamoylbenzoxazol-2-yl)hydroxymethyl]-2-phenylethyl]acetamide
CAS No.:339209-09-5
Molecular Formula:C₃₇H₃₁FN₆O₇
Molecular Weight:690.688
Hs Code.:

2-[5-benzyloxycarbonylamino-2-(4-fluorophenyl)-6-oxo-1,6-dihydro-1-pyrimidinyl]-N-[1-[(5-carbamoylbenzoxazol-2-yl)hydroxymethyl]-2-phenylethyl]acetamide

Synonyms:2-[5-benzyloxycarbonylamino-2-(4-fluorophenyl)-6-oxo-1,6-dihydro-1-pyrimidinyl]-N-[1-[(5-carbamoylbenzoxazol-2-yl)hydroxymethyl]-2-phenylethyl]acetamide

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Chemical Property of 2-[5-benzyloxycarbonylamino-2-(4-fluorophenyl)-6-oxo-1,6-dihydro-1-pyrimidinyl]-N-[1-[(5-carbamoylbenzoxazol-2-yl)hydroxymethyl]-2-phenylethyl]acetamide

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Technology Process of 2-[5-benzyloxycarbonylamino-2-(4-fluorophenyl)-6-oxo-1,6-dihydro-1-pyrimidinyl]-N-[1-[(5-carbamoylbenzoxazol-2-yl)hydroxymethyl]-2-phenylethyl]acetamide

There total 8 articles about 2-[5-benzyloxycarbonylamino-2-(4-fluorophenyl)-6-oxo-1,6-dihydro-1-pyrimidinyl]-N-[1-[(5-carbamoylbenzoxazol-2-yl)hydroxymethyl]-2-phenylethyl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 207235-85-6
2-[5-benzyloxycarbonylamino-2-(4-fluorophenyl)-6-oxo-1,6-dihydro-1-pyrimidinyl]-N-[1-[(5-carboxylbenzoxazol-2-yl)hydroxymethyl]-2-phenylethyl]acetamide

: 339209-09-5
2-[5-benzyloxycarbonylamino-2-(4-fluorophenyl)-6-oxo-1,6-dihydro-1-pyrimidinyl]-N-[1-[(5-carbamoylbenzoxazol-2-yl)hydroxymethyl]-2-phenylethyl]acetamide

Guidance literature:: With ammonium chloride; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethylmorpholine;; In N,N-dimethyl-formamide; at 20 ℃; for 15h;
DOI:10.1021/jm000496v

Reference yield:

: 59830-60-3,63219-70-5,68474-26-0
N-benzyloxycarbonyl-2-amino-3-phenylpropionaldehyde

: 339209-09-5
2-[5-benzyloxycarbonylamino-2-(4-fluorophenyl)-6-oxo-1,6-dihydro-1-pyrimidinyl]-N-[1-[(5-carbamoylbenzoxazol-2-yl)hydroxymethyl]-2-phenylethyl]acetamide

Guidance literature:: Multi-step reaction with 7 steps

1: 94 percent / Et₃N / CH₂Cl₂ / 4 h / 20 °C

2: HCl / CHCl₃ / 3 h / 0 °C

3: ethanol / 6 h / Heating

4: H₂ / 10percent Pd/C / methanol / 18 h / 20 °C

5: 3-hydroxybenzotriazole hydrate; 1-[3(dimethylamino)propyl]-3-ethylcarbodiimide hydrochloride / dimethylformamide / 4 h / 20 °C

6: 81 percent / 1 N aq. NaOH / dimethylsulfoxide / 1 h / 20 °C

7: 78 percent / NH₄Cl; 3-hydroxybenzotriazole hydrate; 1-[3(dimethylamino)propyl]-3-ethylcarbodiimide hydrochloride / N-ethylmorpholine / dimethylformamide / 15 h / 20 °C

With hydrogenchloride; sodium hydroxide; hydrogen; ammonium chloride; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethylmorpholine;; In methanol; ethanol; dichloromethane; chloroform; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jm000496v

Reference yield:

: 536-25-4
methyl 3-amino-4-hydroxybenzoate

: 339209-09-5
2-[5-benzyloxycarbonylamino-2-(4-fluorophenyl)-6-oxo-1,6-dihydro-1-pyrimidinyl]-N-[1-[(5-carbamoylbenzoxazol-2-yl)hydroxymethyl]-2-phenylethyl]acetamide

Guidance literature:: Multi-step reaction with 5 steps

1: ethanol / 6 h / Heating

2: H₂ / 10percent Pd/C / methanol / 18 h / 20 °C

3: 3-hydroxybenzotriazole hydrate; 1-[3(dimethylamino)propyl]-3-ethylcarbodiimide hydrochloride / dimethylformamide / 4 h / 20 °C

4: 81 percent / 1 N aq. NaOH / dimethylsulfoxide / 1 h / 20 °C

5: 78 percent / NH₄Cl; 3-hydroxybenzotriazole hydrate; 1-[3(dimethylamino)propyl]-3-ethylcarbodiimide hydrochloride / N-ethylmorpholine / dimethylformamide / 15 h / 20 °C

With sodium hydroxide; hydrogen; ammonium chloride; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethylmorpholine;; In methanol; ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jm000496v