2-[3-amino-5-(4'-methoxyphenyl)-1H-pyrazol-4-yl]-N,N-diethylacetamide

Base Information

• Chemical Name: 2-[3-amino-5-(4'-methoxyphenyl)-1H-pyrazol-4-yl]-N,N-diethylacetamide
• CAS No.: 386298-19-7
• Molecular Formula: C₁₆H₂₂N₄O₂
• Molecular Weight: 302.376
• Mol file: 386298-19-7.mol

Synonyms:2-[3-amino-5-(4'-methoxyphenyl)-1H-pyrazol-4-yl]-N,N-diethylacetamide

Chemical Property of 2-[3-amino-5-(4'-methoxyphenyl)-1H-pyrazol-4-yl]-N,N-diethylacetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[3-amino-5-(4'-methoxyphenyl)-1H-pyrazol-4-yl]-N,N-diethylacetamide

There total 6 articles about 2-[3-amino-5-(4'-methoxyphenyl)-1H-pyrazol-4-yl]-N,N-diethylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

N,N-diethyl-[3-cyano-4-(4-methoxyphenyl)-4-oxo]butanamide (386298-14-2) → 2-[3-amino-5-(4'-methoxyphenyl)-1H-pyrazol-4-yl]-N,N-diethylacetamide (386298-19-7)

Guidance literature:

With hydrazine hydrate; acetic acid; In ethanol; for 6h; Reflux;

DOI:10.1016/j.bmcl.2010.07.135

Reference yield: 68.0%

3-cyano-N,N-diethyl-4-(4-methoxyphenyl)-4-oxybutanamide → 2-[3-amino-5-(4'-methoxyphenyl)-1H-pyrazol-4-yl]-N,N-diethylacetamide (386298-19-7)

Guidance literature:

With hydrazine hydrate; acetic acid; In ethanol; for 4h; Reflux;

Reference yield:

3-oxo-3-(4'-methoxyphenyl)propanenitrile (3672-47-7) → 2-[3-amino-5-(4'-methoxyphenyl)-1H-pyrazol-4-yl]-N,N-diethylacetamide (386298-19-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 64 percent / sodium iodide; NaOH / ethanol; H₂O / 7 h / 20 °C

2: 68 percent / hydrazine hydrate; acetic acid / ethanol / 4 h / Heating

With sodium hydroxide; hydrazine hydrate; acetic acid; sodium iodide; In ethanol; water;

DOI:10.1016/j.bmc.2005.06.030

upstream raw materials:

N,N-diethyl-[3-cyano-4-(4-methoxyphenyl)-4-oxo]butanamide

methyl 4-methoxybenzoate

3-oxo-3-(4'-methoxyphenyl)propanenitrile

2-Chloro-N,N-diethylacetamide

Downstream raw materials:

2-[2-(4'-methoxyphenyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl]-N,N-diethylacetamide

2-(5,7-diethyl-2-(4-(2-fluoroethoxy)phenyl)-pyrazolo[1,5-a]pyrimidin-3-yl)-N,N-diethylacetamide

C₂₆H₃₅FN₄O₂

C₂₃H₂₉FN₄O₂