methyl (2S)-2-{[(benzylamino)carbonyl]amino}-3-phenylpropanoate

Base Information

• Chemical Name: methyl (2S)-2-{[(benzylamino)carbonyl]amino}-3-phenylpropanoate
• CAS No.: 125369-25-7
• Molecular Formula: C₁₈H₂₀N₂O₃
• Molecular Weight: 312.368
• Mol file: 125369-25-7.mol

Synonyms:methyl (2S)-2-{[(benzylamino)carbonyl]amino}-3-phenylpropanoate

Chemical Property of methyl (2S)-2-{[(benzylamino)carbonyl]amino}-3-phenylpropanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl (2S)-2-{[(benzylamino)carbonyl]amino}-3-phenylpropanoate

There total 10 articles about methyl (2S)-2-{[(benzylamino)carbonyl]amino}-3-phenylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

methyl (2S)-2-amino-3-phenylpropanoate hydrochloride (7524-50-7) + benzyl isothiocyanate (3173-56-6) → methyl (2S)-2-{[(benzylamino)carbonyl]amino}-3-phenylpropanoate (125369-25-7)

Guidance literature:

With triethylamine; In toluene; at 50 ℃; for 16h;

DOI:10.1081/SCC-120003149

Reference yield: 43.0%

methyl (2S)-2-amino-3-phenylpropanoate hydrochloride (7524-50-7) + 1,1'-carbonyldiimidazole (530-62-1) + benzylamine (100-46-9) → methyl (2S)-2-{[(benzylamino)carbonyl]amino}-3-phenylpropanoate (125369-25-7)

Guidance literature:

methyl (2S)-2-amino-3-phenylpropanoate hydrochloride; 1,1'-carbonyldiimidazole; In N,N-dimethyl-formamide; acetonitrile; at 20 ℃; for 2h;

benzylamine; With triethylamine; In N,N-dimethyl-formamide; acetonitrile; at 20 ℃; for 24h;

DOI:10.1016/j.ejmech.2016.10.023

Reference yield:

benzylamine (100-46-9) → methyl (2S)-2-{[(benzylamino)carbonyl]amino}-3-phenylpropanoate (125369-25-7)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene / 4 h / Reflux

2: triethylamine / dichloromethane / 0.5 h / 20 °C / Cooling with ice

With triethylamine; In dichloromethane; toluene;

DOI:10.1016/j.bmc.2012.04.035

upstream raw materials:

di-tert-butyl dicarbonate

methyl (2S)-2-amino-3-phenylpropanoate

benzylamine

methyl (2S)-2-amino-3-phenylpropanoate hydrochloride

Downstream raw materials:

3,5-dibenzyltetrahydro-1H-imidazole-2,4-dione

(S)-2-(3-benzyl-ureido)-N-hydroxy-2-benzyl-acetamide