cis-ethyl 4-((1-(5-(5-(trifluoromethyl)-1H-benzo[d]imidazol-2-yl)pyridin-2-yl)piperidin-4-yl)oxy)cyclohexanecarboxylate

Base Information

Chemical Name:cis-ethyl 4-((1-(5-(5-(trifluoromethyl)-1H-benzo[d]imidazol-2-yl)pyridin-2-yl)piperidin-4-yl)oxy)cyclohexanecarboxylate
CAS No.:1415574-02-5
Molecular Formula:C₂₇H₃₁F₃N₄O₃
Molecular Weight:516.563
Hs Code.:

Synonyms:cis-ethyl 4-((1-(5-(5-(trifluoromethyl)-1H-benzo[d]imidazol-2-yl)pyridin-2-yl)piperidin-4-yl)oxy)cyclohexanecarboxylate

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Chemical Property of cis-ethyl 4-((1-(5-(5-(trifluoromethyl)-1H-benzo[d]imidazol-2-yl)pyridin-2-yl)piperidin-4-yl)oxy)cyclohexanecarboxylate

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Technology Process of cis-ethyl 4-((1-(5-(5-(trifluoromethyl)-1H-benzo[d]imidazol-2-yl)pyridin-2-yl)piperidin-4-yl)oxy)cyclohexanecarboxylate

There total 9 articles about cis-ethyl 4-((1-(5-(5-(trifluoromethyl)-1H-benzo[d]imidazol-2-yl)pyridin-2-yl)piperidin-4-yl)oxy)cyclohexanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1356385-98-2
2-(6-fluoropyridin-3-yl)-5-(trifluoromethyl)-1H-benzo[d]imidazole

: 1415573-47-5
cis ethyl 4-(piperidin-4-yloxy)cyclohexanecarboxylate

: 1415574-02-5
cis-ethyl 4-((1-(5-(5-(trifluoromethyl)-1H-benzo[d]imidazol-2-yl)pyridin-2-yl)piperidin-4-yl)oxy)cyclohexanecarboxylate

Guidance literature:: With sodium hydrogencarbonate; In N,N-dimethyl-formamide; at 110 ℃;

Reference yield:

: 3618-04-0,75877-66-6,17159-80-7
4-hydroxycyclohexyl carboxylic acid ethyl ester

: 1415574-02-5
cis-ethyl 4-((1-(5-(5-(trifluoromethyl)-1H-benzo[d]imidazol-2-yl)pyridin-2-yl)piperidin-4-yl)oxy)cyclohexanecarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 48 h / 55 °C

2: ChiralPak AD-H / Resolution of racemate

3: hydrogen; acetic acid / platinum(IV) oxide

4: sodium hydrogencarbonate / N,N-dimethyl-formamide / 110 °C

With di-isopropyl azodicarboxylate; hydrogen; sodium hydrogencarbonate; acetic acid; triphenylphosphine; platinum(IV) oxide; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 1356385-98-2
2-(6-fluoropyridin-3-yl)-5-(trifluoromethyl)-1H-benzo[d]imidazole

: ethyl 4-(piperidin-4-yloxy)cyclohexanecarboxylate

: 1415574-03-6
trans-ethyl 4-((1-(5-(5-(trifluoromethyl)-1H-benzo[d]imidazol-2-yl)pyridin-2-yl)piperidin-4-yl)oxy)cyclohexanecarboxylate

: 1415574-02-5
cis-ethyl 4-((1-(5-(5-(trifluoromethyl)-1H-benzo[d]imidazol-2-yl)pyridin-2-yl)piperidin-4-yl)oxy)cyclohexanecarboxylate

Guidance literature:: With sodium hydrogencarbonate; In 1-methyl-pyrrolidin-2-one; at 110 ℃; Overall yield = 9.1 g; Inert atmosphere;
DOI:10.1021/ml5003426