3-(tert-butyloxycarbonylamino)-4-hydroxy-1-(3,4-dimethoxyphenyl)butan-1-one

Base Information

Chemical Name:3-(tert-butyloxycarbonylamino)-4-hydroxy-1-(3,4-dimethoxyphenyl)butan-1-one
CAS No.:1434254-03-1
Molecular Formula:C₁₇H₂₅NO₆
Molecular Weight:339.389
Hs Code.:

Synonyms:3-(tert-butyloxycarbonylamino)-4-hydroxy-1-(3,4-dimethoxyphenyl)butan-1-one

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Chemical Property of 3-(tert-butyloxycarbonylamino)-4-hydroxy-1-(3,4-dimethoxyphenyl)butan-1-one

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Technology Process of 3-(tert-butyloxycarbonylamino)-4-hydroxy-1-(3,4-dimethoxyphenyl)butan-1-one

There total 8 articles about 3-(tert-butyloxycarbonylamino)-4-hydroxy-1-(3,4-dimethoxyphenyl)butan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1434253-95-8
2-Boc-amino-3-[2-(3,4-dimethoxyphenyl)-1,3-dithian-2-yl]propan-1-ol

: 1434254-03-1
3-(tert-butyloxycarbonylamino)-4-hydroxy-1-(3,4-dimethoxyphenyl)butan-1-one

Guidance literature:: With water; iodine; sodium hydrogencarbonate; In acetonitrile;
DOI:10.1016/j.tetasy.2015.04.016

Reference yield:

: 1434253-95-8
2-Boc-amino-3-[2-(3,4-dimethoxyphenyl)-1,3-dithian-2-yl]propan-1-ol

: 1434254-03-1
3-(tert-butyloxycarbonylamino)-4-hydroxy-1-(3,4-dimethoxyphenyl)butan-1-one

: C₁₇H₂₅NO₆

Guidance literature:: With iodine; sodium hydrogencarbonate; In acetonitrile; at 0 - 30 ℃; for 1h; Overall yield = 94 %; Overall yield = 637 mg;
DOI:10.1002/ejoc.201201128

Reference yield:

: 50766-67-1
2-(3,4-dimethoxyphenyl)-1,3-dithiane

: 1434254-03-1
3-(tert-butyloxycarbonylamino)-4-hydroxy-1-(3,4-dimethoxyphenyl)butan-1-one

: C₁₇H₂₅NO₆

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.67 h / -20 °C

1.2: -20 °C

2.1: trifluoroacetic acid / methanol / 0 °C

3.1: sodium hydrogencarbonate; iodine / acetonitrile / 1 h / 0 - 30 °C

With n-butyllithium; iodine; sodium hydrogencarbonate; trifluoroacetic acid; In tetrahydrofuran; methanol; hexane; acetonitrile;
DOI:10.1002/ejoc.201201128