5-{2-[((R)-5-Methoxy-1,2,3,4-tetrahydro-naphthalen-1-ylmethyl)-methyl-amino]-ethyl}-2-nitro-phenol

Base Information

• Chemical Name: 5-{2-[((R)-5-Methoxy-1,2,3,4-tetrahydro-naphthalen-1-ylmethyl)-methyl-amino]-ethyl}-2-nitro-phenol
• CAS No.: 1026370-75-1
• Molecular Formula: C₂₁H₂₆N₂O₄
• Molecular Weight: 370.448
• Mol file: 1026370-75-1.mol

Synonyms:5-{2-[((R)-5-Methoxy-1,2,3,4-tetrahydro-naphthalen-1-ylmethyl)-methyl-amino]-ethyl}-2-nitro-phenol

Chemical Property of 5-{2-[((R)-5-Methoxy-1,2,3,4-tetrahydro-naphthalen-1-ylmethyl)-methyl-amino]-ethyl}-2-nitro-phenol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-{2-[((R)-5-Methoxy-1,2,3,4-tetrahydro-naphthalen-1-ylmethyl)-methyl-amino]-ethyl}-2-nitro-phenol

There total 4 articles about 5-{2-[((R)-5-Methoxy-1,2,3,4-tetrahydro-naphthalen-1-ylmethyl)-methyl-amino]-ethyl}-2-nitro-phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(3-Hydroxy-4-nitro-phenyl)-N-((R)-5-methoxy-1,2,3,4-tetrahydro-naphthalen-1-ylmethyl)-N-methyl-acetamide (1027146-93-5) → 5-{2-[((R)-5-Methoxy-1,2,3,4-tetrahydro-naphthalen-1-ylmethyl)-methyl-amino]-ethyl}-2-nitro-phenol (1026370-75-1)

Guidance literature:

With borane-THF; In tetrahydrofuran; for 5h; Heating;

DOI:10.1021/jm960723m

Reference yield:

(3-Hydroxy-4-nitro-phenyl)-acetonitrile (957273-65-3) → 5-{2-[((R)-5-Methoxy-1,2,3,4-tetrahydro-naphthalen-1-ylmethyl)-methyl-amino]-ethyl}-2-nitro-phenol (1026370-75-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 2.5M aq. NaOH

2: 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride, 1-hydroxybenzotriazole / tetrahydrofuran / 18 h / Ambient temperature

3: BH₃*THF / tetrahydrofuran / 5 h / Heating

With sodium hydroxide; borane-THF; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran;

DOI:10.1021/jm960723m

Reference yield:

(3-hydroxy-4-nitro-phenyl)-acetic acid (152148-79-3) → 5-{2-[((R)-5-Methoxy-1,2,3,4-tetrahydro-naphthalen-1-ylmethyl)-methyl-amino]-ethyl}-2-nitro-phenol (1026370-75-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride, 1-hydroxybenzotriazole / tetrahydrofuran / 18 h / Ambient temperature

2: BH₃*THF / tetrahydrofuran / 5 h / Heating

With borane-THF; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran;

DOI:10.1021/jm960723m

upstream raw materials:

2-(3-Hydroxy-4-nitro-phenyl)-N-((R)-5-methoxy-1,2,3,4-tetrahydro-naphthalen-1-ylmethyl)-N-methyl-acetamide

(3-Hydroxy-4-nitro-phenyl)-acetonitrile

(3-hydroxy-4-nitro-phenyl)-acetic acid

5-(bromomethyl)-2-nitrophenol

Downstream raw materials:

2-Amino-5-{2-[((R)-5-methoxy-1,2,3,4-tetrahydro-naphthalen-1-ylmethyl)-methyl-amino]-ethyl}-phenol