C₂₇H₃₄F₂N₄O₄

Base Information

Chemical Name:C₂₇H₃₄F₂N₄O₄
CAS No.:1609348-04-0
Molecular Formula:C₂₇H₃₄F₂N₄O₄
Molecular Weight:516.588
Hs Code.:

C<sub>27</sub>H<sub>34</sub>F<sub>2</sub>N<sub>4</sub>O<sub>4</sub>

Synonyms:C₂₇H₃₄F₂N₄O₄

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of C₂₇H₃₄F₂N₄O₄

Chemical Property:

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Technology Process of C₂₇H₃₄F₂N₄O₄

There total 9 articles about C₂₇H₃₄F₂N₄O₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 754230-78-9
3-(benzyloxy)-5-bromopyridine-2-amine

: 1609348-04-0
C₂₇H₃₄F₂N₄O₄

: 1609348-05-1
C₂₇H₃₄F₂N₄O₄

Guidance literature:: Multi-step reaction with 7 steps

1.1: ethanol / 72 h / Inert atmosphere; Molecular sieve; Reflux

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane / 8 h / Inert atmosphere; Reflux

3.1: hydrogen; palladium 10% on activated carbon / ethanol; water; dichloromethane / 20 °C / 760.05 Torr / Inert atmosphere

4.1: caesium carbonate / N,N-dimethyl-formamide / 5 h / 60 °C

5.1: water; lithium hydroxide / methanol; tetrahydrofuran / 16 h / 20 °C

6.1: 4-methyl-morpholine; HATU / N,N-dimethyl-formamide / 0.33 h / 20 °C

6.2: 20 °C

7.1: Daicel Chiralpak IA / acetonitrile; tert-butyl methyl ether / 25 °C / Resolution of racemate

With 4-methyl-morpholine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; water; hydrogen; potassium carbonate; caesium carbonate; HATU; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; tert-butyl methyl ether; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1609348-38-0
rac-tert-butyl {1-[({8-[(2,6-difluorobenzyl)oxy]-2,6-dimethylimidazo[1,2-a]pyridin-3-yl}carbonyl)amino]-3-methylbutan-2-yl}carbamate

: 1609348-04-0
C₂₇H₃₄F₂N₄O₄

: 1609348-05-1
C₂₇H₃₄F₂N₄O₄

Guidance literature:: With Daicel Chiralpak IA; In tert-butyl methyl ether; acetonitrile; at 25 ℃; Resolution of racemate;

Reference yield:

: 24016-03-3
2-amino-3-benzyloxypyridine

: 1609348-04-0
C₂₇H₃₄F₂N₄O₄

: 1609348-05-1
C₂₇H₃₄F₂N₄O₄

Guidance literature:: Multi-step reaction with 8 steps

1.1: bromine / dichloromethane / 1.5 h / 0 °C

2.1: ethanol / 72 h / Inert atmosphere; Molecular sieve; Reflux

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane / 8 h / Inert atmosphere; Reflux

4.1: hydrogen; palladium 10% on activated carbon / ethanol; water; dichloromethane / 20 °C / 760.05 Torr / Inert atmosphere

5.1: caesium carbonate / N,N-dimethyl-formamide / 5 h / 60 °C

6.1: water; lithium hydroxide / methanol; tetrahydrofuran / 16 h / 20 °C

7.1: 4-methyl-morpholine; HATU / N,N-dimethyl-formamide / 0.33 h / 20 °C

7.2: 20 °C

8.1: Daicel Chiralpak IA / acetonitrile; tert-butyl methyl ether / 25 °C / Resolution of racemate

With 4-methyl-morpholine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; water; hydrogen; bromine; potassium carbonate; caesium carbonate; HATU; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; tert-butyl methyl ether; water; N,N-dimethyl-formamide; acetonitrile;