rac-tert-butyl {1-[({8-[(2,6-difluorobenzyl)oxy]-2,6-dimethylimidazo[1,2-a]pyridin-3-yl}carbonyl)amino]-3-methylbutan-2-yl}carbamate

Base Information

Chemical Name:rac-tert-butyl {1-[({8-[(2,6-difluorobenzyl)oxy]-2,6-dimethylimidazo[1,2-a]pyridin-3-yl}carbonyl)amino]-3-methylbutan-2-yl}carbamate
CAS No.:1609348-38-0
Molecular Formula:C₂₇H₃₄F₂N₄O₄
Molecular Weight:516.588
Hs Code.:

Synonyms:rac-tert-butyl {1-[({8-[(2,6-difluorobenzyl)oxy]-2,6-dimethylimidazo[1,2-a]pyridin-3-yl}carbonyl)amino]-3-methylbutan-2-yl}carbamate

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Chemical Property of rac-tert-butyl {1-[({8-[(2,6-difluorobenzyl)oxy]-2,6-dimethylimidazo[1,2-a]pyridin-3-yl}carbonyl)amino]-3-methylbutan-2-yl}carbamate

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Technology Process of rac-tert-butyl {1-[({8-[(2,6-difluorobenzyl)oxy]-2,6-dimethylimidazo[1,2-a]pyridin-3-yl}carbonyl)amino]-3-methylbutan-2-yl}carbamate

There total 8 articles about rac-tert-butyl {1-[({8-[(2,6-difluorobenzyl)oxy]-2,6-dimethylimidazo[1,2-a]pyridin-3-yl}carbonyl)amino]-3-methylbutan-2-yl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 871235-24-4,400652-50-8
2-methyl-2-propanyl (1-amino-3-methyl-2-butanyl)carbamate

: 1609082-37-2
8-[(2,6-difluorobenzyl)oxy]-2,6-dimethylimidazo[1,2-a]pyridine-3-carboxylic acid

: 1609348-38-0
rac-tert-butyl {1-[({8-[(2,6-difluorobenzyl)oxy]-2,6-dimethylimidazo[1,2-a]pyridin-3-yl}carbonyl)amino]-3-methylbutan-2-yl}carbamate

Guidance literature:: 8-[(2,6-difluorobenzyl)oxy]-2,6-dimethylimidazo[1,2-a]pyridine-3-carboxylic acid; With 4-methyl-morpholine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 0.333333h;

2-methyl-2-propanyl (1-amino-3-methyl-2-butanyl)carbamate; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 754230-78-9
3-(benzyloxy)-5-bromopyridine-2-amine

: 1609348-38-0
rac-tert-butyl {1-[({8-[(2,6-difluorobenzyl)oxy]-2,6-dimethylimidazo[1,2-a]pyridin-3-yl}carbonyl)amino]-3-methylbutan-2-yl}carbamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: ethanol / 72 h / Inert atmosphere; Molecular sieve; Reflux

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane / 8 h / Inert atmosphere; Reflux

3.1: hydrogen; palladium 10% on activated carbon / ethanol; water; dichloromethane / 20 °C / 760.05 Torr / Inert atmosphere

4.1: caesium carbonate / N,N-dimethyl-formamide / 5 h / 60 °C

5.1: water; lithium hydroxide / methanol; tetrahydrofuran / 16 h / 20 °C

6.1: 4-methyl-morpholine; HATU / N,N-dimethyl-formamide / 0.33 h / 20 °C

6.2: 20 °C

With 4-methyl-morpholine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; water; hydrogen; potassium carbonate; caesium carbonate; HATU; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1609082-36-1
ethyl 8-[(2,6-difluorobenzyl)oxy]-2,6-dimethylimidazo[1,2-a]pyridine-3-carboxylate

: 1609348-38-0
rac-tert-butyl {1-[({8-[(2,6-difluorobenzyl)oxy]-2,6-dimethylimidazo[1,2-a]pyridin-3-yl}carbonyl)amino]-3-methylbutan-2-yl}carbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: water; lithium hydroxide / methanol; tetrahydrofuran / 16 h / 20 °C

2.1: 4-methyl-morpholine; HATU / N,N-dimethyl-formamide / 0.33 h / 20 °C

2.2: 20 °C

With 4-methyl-morpholine; water; HATU; lithium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;