2-[(dibenzyloxyphosphoryloxy)methyl]-4-[(2-oxo-2H-1-benzopyran-7-yl)oxy]butane-1,2-diyl bis(dibenzylphosphate)

Base Information

Chemical Name:2-[(dibenzyloxyphosphoryloxy)methyl]-4-[(2-oxo-2H-1-benzopyran-7-yl)oxy]butane-1,2-diyl bis(dibenzylphosphate)
CAS No.:633308-18-6
Molecular Formula:C₅₆H₅₅O₁₅P₃
Molecular Weight:1060.96
Hs Code.:

Synonyms:2-[(dibenzyloxyphosphoryloxy)methyl]-4-[(2-oxo-2H-1-benzopyran-7-yl)oxy]butane-1,2-diyl bis(dibenzylphosphate)

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Chemical Property of 2-[(dibenzyloxyphosphoryloxy)methyl]-4-[(2-oxo-2H-1-benzopyran-7-yl)oxy]butane-1,2-diyl bis(dibenzylphosphate)

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Technology Process of 2-[(dibenzyloxyphosphoryloxy)methyl]-4-[(2-oxo-2H-1-benzopyran-7-yl)oxy]butane-1,2-diyl bis(dibenzylphosphate)

There total 7 articles about 2-[(dibenzyloxyphosphoryloxy)methyl]-4-[(2-oxo-2H-1-benzopyran-7-yl)oxy]butane-1,2-diyl bis(dibenzylphosphate) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

: 108549-23-1
Dibenzyl N,N-diisopropylphosphoramidite

: 633308-08-4
7-[3,4-dihydroxy-3-(hydroxymethyl)butoxy]-2H-1-benzopyran-2-one

: 633308-18-6
2-[(dibenzyloxyphosphoryloxy)methyl]-4-[(2-oxo-2H-1-benzopyran-7-yl)oxy]butane-1,2-diyl bis(dibenzylphosphate)

Guidance literature:: Dibenzyl N,N-diisopropylphosphoramidite; 7-[3,4-dihydroxy-3-(hydroxymethyl)butoxy]-2H-1-benzopyran-2-one; With 1H-tetrazole; In dichloromethane; N,N-dimethyl-formamide; at 25 ℃; for 3h;

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; N,N-dimethyl-formamide; at 0 ℃; for 1h;
DOI:10.1002/hlca.200390199

Reference yield:

: 127205-14-5
2,2-dimethyl-5-hydroxy-5-(2'-hydroxyethyl)-1,3-dioxane

: 633308-18-6
2-[(dibenzyloxyphosphoryloxy)methyl]-4-[(2-oxo-2H-1-benzopyran-7-yl)oxy]butane-1,2-diyl bis(dibenzylphosphate)

Guidance literature:: Multi-step reaction with 4 steps

1.1: 62 percent / pyridine / 72 h / 5 °C

2.1: 87 percent / K₂CO₃ / 18-crown-6 ether / dimethylformamide / 12 h / 95 °C

3.1: 100 percent / aq. HCl / tetrahydrofuran / 1 h

4.1: 1H-tetrazole / CH₂Cl₂; dimethylformamide / 3 h / 25 °C

4.2: 27 percent / m-CPBA / CH₂Cl₂; dimethylformamide / 1 h / 0 °C

With pyridine; 1H-tetrazole; hydrogenchloride; potassium carbonate; 18-crown-6 ether; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/hlca.200390199

Reference yield:

: 127218-61-5
2-(5-hydroxy-2,2-dimethyl-1,3-dioxan-5-yl)ethyl 4-methylbenzenesulfonate

: 633308-18-6
2-[(dibenzyloxyphosphoryloxy)methyl]-4-[(2-oxo-2H-1-benzopyran-7-yl)oxy]butane-1,2-diyl bis(dibenzylphosphate)

Guidance literature:: Multi-step reaction with 3 steps

1.1: 87 percent / K₂CO₃ / 18-crown-6 ether / dimethylformamide / 12 h / 95 °C

2.1: 100 percent / aq. HCl / tetrahydrofuran / 1 h

3.1: 1H-tetrazole / CH₂Cl₂; dimethylformamide / 3 h / 25 °C

3.2: 27 percent / m-CPBA / CH₂Cl₂; dimethylformamide / 1 h / 0 °C

With 1H-tetrazole; hydrogenchloride; potassium carbonate; 18-crown-6 ether; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/hlca.200390199