(7,8-Dichloro-2-hydroxymethyl-2,3-dihydro-benzo[1,4]dioxin-5-yl)-phenyl-methanone

Base Information

• Chemical Name: (7,8-Dichloro-2-hydroxymethyl-2,3-dihydro-benzo[1,4]dioxin-5-yl)-phenyl-methanone
• CAS No.: 103829-82-9
• Molecular Formula: C₁₆H₁₂Cl₂O₄
• Molecular Weight: 339.175
• Mol file: 103829-82-9.mol

Synonyms:(7,8-Dichloro-2-hydroxymethyl-2,3-dihydro-benzo[1,4]dioxin-5-yl)-phenyl-methanone

Chemical Property of (7,8-Dichloro-2-hydroxymethyl-2,3-dihydro-benzo[1,4]dioxin-5-yl)-phenyl-methanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (7,8-Dichloro-2-hydroxymethyl-2,3-dihydro-benzo[1,4]dioxin-5-yl)-phenyl-methanone

There total 1 articles about (7,8-Dichloro-2-hydroxymethyl-2,3-dihydro-benzo[1,4]dioxin-5-yl)-phenyl-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

benzoyl chloride (98-88-4) + 7,8-dichloro-2,3-dihydro-1,4-benzodioxin-2-ylmethanol (103829-58-9) → (7,8-Dichloro-2-hydroxymethyl-2,3-dihydro-benzo[1,4]dioxin-6-yl)-phenyl-methanone (103829-83-0) + (7,8-Dichloro-2-hydroxymethyl-2,3-dihydro-benzo[1,4]dioxin-5-yl)-phenyl-methanone (103829-82-9)

Guidance literature:

With sodium hydroxide; aluminium trichloride; Product distribution; 1.) CH₂Cl₂, r.t., 30 min, 90 deg C, 2.5 h, 2.) EtOH, reflux, 30 min; various reagent ratio;

DOI:10.1248/cpb.36.3404

Reference yield: 80.7%

(7,8-Dichloro-2-hydroxymethyl-2,3-dihydro-benzo[1,4]dioxin-5-yl)-phenyl-methanone (103829-82-9) → 5-Benzoyl-7,8-dichloro-2,3-dihydro-benzo[1,4]dioxine-2-carboxylic acid (103830-19-9)

Guidance literature:

With sulfuric acid; chromic acid; In acetone; Ambient temperature;

DOI:10.1248/cpb.36.3404

upstream raw materials:

benzoyl chloride

7,8-dichloro-2,3-dihydro-1,4-benzodioxin-2-ylmethanol

Downstream raw materials:

5-Benzoyl-7,8-dichloro-2,3-dihydro-benzo[1,4]dioxine-2-carboxylic acid