2'-amino-3'-O-[2-cyanoethoxy(diisopropylamino)phosphino]-5'O-dimethoxytrityl-2'-N,4'-C-oxomethylene thymidine

Base Information

Chemical Name:2'-amino-3'-O-[2-cyanoethoxy(diisopropylamino)phosphino]-5'O-dimethoxytrityl-2'-N,4'-C-oxomethylene thymidine
CAS No.:1300589-96-1
Molecular Formula:C₄₁H₄₈N₅O₉P
Molecular Weight:785.834
Hs Code.:

Synonyms:2'-amino-3'-O-[2-cyanoethoxy(diisopropylamino)phosphino]-5'O-dimethoxytrityl-2'-N,4'-C-oxomethylene thymidine

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Chemical Property of 2'-amino-3'-O-[2-cyanoethoxy(diisopropylamino)phosphino]-5'O-dimethoxytrityl-2'-N,4'-C-oxomethylene thymidine

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Technology Process of 2'-amino-3'-O-[2-cyanoethoxy(diisopropylamino)phosphino]-5'O-dimethoxytrityl-2'-N,4'-C-oxomethylene thymidine

There total 6 articles about 2'-amino-3'-O-[2-cyanoethoxy(diisopropylamino)phosphino]-5'O-dimethoxytrityl-2'-N,4'-C-oxomethylene thymidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

: 1300589-93-8
C₃₂H₃₁N₃O₈

: 102691-36-1
N,N,N',N'-tetraisopropyl 2-cyanoethylphosphorodiamidite

: 1300589-96-1
2'-amino-3'-O-[2-cyanoethoxy(diisopropylamino)phosphino]-5'O-dimethoxytrityl-2'-N,4'-C-oxomethylene thymidine

Guidance literature:: With N,N-diisopropylamine tetrazolide; In tetrahydrofuran; acetonitrile; for 1.5h; Inert atmosphere;

Reference yield:

: 153186-10-8
((3aR,5R,6S,6aR)-6-(benzyloxy)-5-((benzyloxy)methyl)-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)methanol

: 1300589-96-1
2'-amino-3'-O-[2-cyanoethoxy(diisopropylamino)phosphino]-5'O-dimethoxytrityl-2'-N,4'-C-oxomethylene thymidine

Guidance literature:: Multi-step reaction with 5 steps

1: dmap; triethylamine / dichloromethane / 20 h / Inert atmosphere; Cooling; Reflux

2: sulfuric acid; acetic acid / 3.5 h

3: hydrogen / 10 wt% Pd(OH)2 on carbon / tetrahydrofuran / 3 h / Inert atmosphere

4: pyridine / 3 h / Inert atmosphere

5: N,N-diisopropylamine tetrazolide / acetonitrile; tetrahydrofuran / 1.5 h / Inert atmosphere

With pyridine; dmap; sulfuric acid; N,N-diisopropylamine tetrazolide; hydrogen; acetic acid; triethylamine; 10 wt% Pd(OH)2 on carbon; In tetrahydrofuran; dichloromethane; acetonitrile;

Reference yield:

: 3,5-di-O-benzyl-4-C-(tert-butyldiphenylsilyloxymethyl)-1,2-O-isopropylidene-α-D-ribofuranose

: 1300589-96-1
2'-amino-3'-O-[2-cyanoethoxy(diisopropylamino)phosphino]-5'O-dimethoxytrityl-2'-N,4'-C-oxomethylene thymidine

Guidance literature:: Multi-step reaction with 4 steps

1: sulfuric acid; acetic acid / 3.5 h

2: hydrogen / 10 wt% Pd(OH)2 on carbon / tetrahydrofuran / 3 h / Inert atmosphere

3: pyridine / 3 h / Inert atmosphere

4: N,N-diisopropylamine tetrazolide / acetonitrile; tetrahydrofuran / 1.5 h / Inert atmosphere

With pyridine; sulfuric acid; N,N-diisopropylamine tetrazolide; hydrogen; acetic acid; 10 wt% Pd(OH)2 on carbon; In tetrahydrofuran; acetonitrile;