2,4,4',6'-tetramethoxymethoxy-2'-hydroxy-3'-(1'-geranyl)-chalcone

Base Information

• Chemical Name: 2,4,4',6'-tetramethoxymethoxy-2'-hydroxy-3'-(1'-geranyl)-chalcone
• CAS No.: 213892-93-4
• Molecular Formula: C₃₃H₄₄O₁₀
• Molecular Weight: 600.706
• Mol file: 213892-93-4.mol

Synonyms:2,4,4',6'-tetramethoxymethoxy-2'-hydroxy-3'-(1'-geranyl)-chalcone

Chemical Property of 2,4,4',6'-tetramethoxymethoxy-2'-hydroxy-3'-(1'-geranyl)-chalcone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,4,4',6'-tetramethoxymethoxy-2'-hydroxy-3'-(1'-geranyl)-chalcone

There total 3 articles about 2,4,4',6'-tetramethoxymethoxy-2'-hydroxy-3'-(1'-geranyl)-chalcone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

2,4-bis(methoxymethoxy)benzaldehyde (13709-06-3) + 1-{3-[(2E)-3,7-dimethylocta-2,6-dien-1-yl]-2-hydroxy-4,6-bis(methoxymethoxy)phenyl}ethanone (328946-43-6) → 2,4,4',6'-tetramethoxymethoxy-2'-hydroxy-3'-(1'-geranyl)-chalcone (213892-93-4)

Guidance literature:

With potassium hydroxide; In methanol; ethanol; 1) 0 deg C, 3 h; 2( rt, 33 h;

DOI:10.1021/np980026s

Reference yield:

1-{3-[(2E)-3,7-dimethylocta-2,6-dien-1-yl]-2,4,6-trihydroxyphenyl}ethanone (43230-44-0,43230-43-9) → 2,4,4',6'-tetramethoxymethoxy-2'-hydroxy-3'-(1'-geranyl)-chalcone (213892-93-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 65 percent / K₂CO₃ / acetone / 1.5 h / Heating

2: 40 percent / potassium hydroxide / methanol; ethanol / 1) 0 deg C, 3 h; 2( rt, 33 h

With potassium hydroxide; potassium carbonate; In methanol; ethanol; acetone;

DOI:10.1021/np980026s

Reference yield:

2,4,6-trihydroxyacetophenone (480-66-0,67471-34-5) → 2,4,4',6'-tetramethoxymethoxy-2'-hydroxy-3'-(1'-geranyl)-chalcone (213892-93-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 78 percent / potassium carbonate / acetone / 6 h / Heating

2: 65 percent / K₂CO₃ / acetone / 1.5 h / Heating

3: 40 percent / potassium hydroxide / methanol; ethanol / 1) 0 deg C, 3 h; 2( rt, 33 h

With potassium hydroxide; potassium carbonate; In methanol; ethanol; acetone;

DOI:10.1021/np980026s

upstream raw materials:

2,4-bis(methoxymethoxy)benzaldehyde

1-{3-[(2E)-3,7-dimethylocta-2,6-dien-1-yl]-2-hydroxy-4,6-bis(methoxymethoxy)phenyl}ethanone

2,4,6-trihydroxyacetophenone

1-{3-[(2E)-3,7-dimethylocta-2,6-dien-1-yl]-2,4,6-trihydroxyphenyl}ethanone

Downstream raw materials:

(R,S)-sophoraflavanone C

(R,S)-5,7,2',4'-tetramethoxymethoxy-8-(1'-geranyl)flavanone