1-{3-[(2E)-3,7-dimethylocta-2,6-dien-1-yl]-2-hydroxy-4,6-bis(methoxymethoxy)phenyl}ethanone

Base Information

• Chemical Name: 1-{3-[(2E)-3,7-dimethylocta-2,6-dien-1-yl]-2-hydroxy-4,6-bis(methoxymethoxy)phenyl}ethanone
• CAS No.: 328946-43-6
• Molecular Formula: C₂₂H₃₂O₆
• Molecular Weight: 392.492
• Mol file: 328946-43-6.mol

Synonyms:1-{3-[(2E)-3,7-dimethylocta-2,6-dien-1-yl]-2-hydroxy-4,6-bis(methoxymethoxy)phenyl}ethanone

Chemical Property of 1-{3-[(2E)-3,7-dimethylocta-2,6-dien-1-yl]-2-hydroxy-4,6-bis(methoxymethoxy)phenyl}ethanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-{3-[(2E)-3,7-dimethylocta-2,6-dien-1-yl]-2-hydroxy-4,6-bis(methoxymethoxy)phenyl}ethanone

There total 4 articles about 1-{3-[(2E)-3,7-dimethylocta-2,6-dien-1-yl]-2-hydroxy-4,6-bis(methoxymethoxy)phenyl}ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

1-{3-[(2E)-3,7-dimethylocta-2,6-dien-1-yl]-2,4,6-trihydroxyphenyl}ethanone (43230-44-0,43230-43-9) + chloromethyl methyl ether (107-30-2) → 1-{3-[(2E)-3,7-dimethylocta-2,6-dien-1-yl]-2-hydroxy-4,6-bis(methoxymethoxy)phenyl}ethanone (328946-43-6)

Guidance literature:

With triisopropylamine; In dichloromethane; at 20 ℃; for 4h; Inert atmosphere;

DOI:10.1002/hlca.200900251

Reference yield:

2,4,6-trihydroxyacetophenone (480-66-0,67471-34-5) → 1-{3-[(2E)-3,7-dimethylocta-2,6-dien-1-yl]-2-hydroxy-4,6-bis(methoxymethoxy)phenyl}ethanone (328946-43-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 78 percent Turnov_. / potassium carbonate / acetone / 6 h / Heating

2: 65 percent / K₂CO₃ / acetone / 1.5 h / Heating

With potassium carbonate; In acetone; 1: Alkylation / 2: Alkylation;

Reference yield:

trans-geranyl bromide (6138-90-5) → 1-{3-[(2E)-3,7-dimethylocta-2,6-dien-1-yl]-2-hydroxy-4,6-bis(methoxymethoxy)phenyl}ethanone (328946-43-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 78 percent Turnov_. / potassium carbonate / acetone / 6 h / Heating

2: 65 percent / K₂CO₃ / acetone / 1.5 h / Heating

With potassium carbonate; In acetone; 1: Alkylation / 2: Alkylation;

upstream raw materials:

1-{3-[(2E)-3,7-dimethylocta-2,6-dien-1-yl]-2,4,6-trihydroxyphenyl}ethanone

chloromethyl methyl ether

trans-geranyl bromide

2,4,6-trihydroxyacetophenone

Downstream raw materials:

2,4,4',6'-tetramethoxymethoxy-2'-hydroxy-3'-(1'-geranyl)-chalcone

4',6'-dimethoxymethoxy-2'-hydroxy-3'-(1-geranyl)chalcone

4,6-Bis[(methoxy)methoxy]-2-methoxy-3-(1'-geranyl)acetophenone

(+/-)-5,7-Dihydroxy-6-(1''-geranyl)flavanone